Title:
ATP7Aの使用による、神経変性疾患の治療
Document Type and Number:
Japanese Patent JP2007523893
Kind Code:
A
Abstract:
The invention relates to the use of a ATP7A-interacting molecule for the preparation of a pharmaceutical composition for the treatment of a neurogenerative disease. Hereby the ATP7A-interacting molecule is preferably an inhibitor of ATP7A and particularly it has the capacity to modulate the activity of gamma-secretase and/or beta-secretase. Furthermore the invention concerns a process for identifying a gamma-secretase and/or a beta-secretase modulator comprising the following steps: a. identifying of a ATP7A-interacting molecule by determining whether a given test compound is a ATP7A-interacting molecule, b. determining whether the ATP7A-interacting molecule of step a) is capable of modulating gamma-secretase and/or beta-secretase activity.
Inventors:
Hopf, Karsten
Drews, Gerald
Raffner, Heinz
Drews, Gerald
Raffner, Heinz
Application Number:
JP2006549894A
Publication Date:
August 23, 2007
Filing Date:
November 29, 2004
Export Citation:
Assignee:
CELLZOME AG
International Classes:
A61K45/00; A61K31/7088; A61K31/713; A61K38/55; A61K39/395; A61K48/00; A61P25/28; A61P43/00; C12N9/14; C12N15/113; C12Q1/37; C12Q1/42; G01N33/15; G01N33/50; C12N9/99; C12N15/09
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho