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Title:
可溶性FcγR融合タンパク質およびその使用法
Document Type and Number:
Japanese Patent JP2007525149
Kind Code:
A
Abstract:
The present invention relates to molecules, preferably soluble (i.e., not membrane bound) polypeptides, most preferably soluble fusion polypeptides comprising the extracellular soluble regions of an Fc³R, derivatives and analogs thereof, and nucleic acids encoding the same. Molecules of the invention are particularly useful for the treatment, management, or prevention of, or amelioration of one or more symptoms of an autoimmune disease, especially for ameliorating serum platelet deficiency associated with immune thrombocytopenic purpura. The invention provides methods and compositions for enhancing the therapeutic efficacy of standard, current or experimental therapies for an autoimmune disease by administering a molecule of the invention.

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Inventors:
Johnson, Leslie, Es.
Li, Hua
Twin Iron, Nadine
Application Number:
JP2006500914A
Publication Date:
September 06, 2007
Filing Date:
January 13, 2004
Export Citation:
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Assignee:
Macrogenics, Incorporated
International Classes:
C12N15/09; A61K6/00; A61K31/192; A61K31/42; A61K31/519; A61K31/616; A61K38/00; A61K38/17; A61K39/395; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P37/00; A61P37/02; A61P37/06; C07K14/735; C07K16/18; C07K16/28; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/13; C12N15/62; C12P21/02; C12P21/08; A61K
Domestic Patent References:
JP2000511402A2000-09-05
JPH09511644A1997-11-25
Foreign References:
WO1999002681A11999-01-21
Other References:
JPN6009062731, Ｍｏｌｅｃｕｌａｒ　Ｉｍｍｕｎｏｌｏｇｙ, 2001, Ｖｏｌ．３８, ｐ．５２７−５３８
JPN6009062734, Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ, 2001, Ｖｏｌ．２７６，　Ｎｏ．１９, ｐ．１６４６９−１６４７７
JPN6009062738, Ｓｃｉｅｎｃｅ, 2001, ＶＯｌ．２９１, ｐ．４８４−４８６
JPN6009062736, Ｂｌｏｏｄ, 1993, Ｖｏｌ．８１，　Ｎｏ．１, ｐ．１５−１９
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita



 
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