Title:
修飾iRNA剤
Document Type and Number:
Japanese Patent JP2007525454
Kind Code:
A
Abstract:
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety, e.g., cholesterol, is directly, or indirectly, tethered. The invention also relates to methods of making and using such modified iRNA agents.
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Inventors:
Manoharlan, Musia
Application Number:
JP2006513077A
Publication Date:
September 06, 2007
Filing Date:
April 16, 2004
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS, INC.
International Classes:
C07H21/02; A61K31/70; A61K31/712; A61K48/00; A61P31/14; A61P35/00; A61P35/02; C07D473/14; C07F9/24; C07F9/572; C07H21/04; C12N15/09; C12Q1/68; A61L2/16; C07K7/06; C07K7/08; C07K14/155
Domestic Patent References:
| JPH06500556A | 1994-01-20 |
Foreign References:
| US5652359A | 1997-07-29 |
Other References:
JPN6010018368, ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ, 1994, ５４（２２）, ｐｐ．５７８３−５７８７
JPN6010018369, Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ, 1989, ｖｏｌ．８６, ｐｐ．６５５３−６５５６
JPN6010018370, ＮＡＴＵＲＥ ＲＥＶＩＥＷＳ ＤＲＵＧ ＤＩＳＣＯＶＥＲＹ, 2002, ｖｏ．１, ｐｐ．５０３−５１４
JPN6010018369, Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ, 1989, ｖｏｌ．８６, ｐｐ．６５５３−６５５６
JPN6010018370, ＮＡＴＵＲＥ ＲＥＶＩＥＷＳ ＤＲＵＧ ＤＩＳＣＯＶＥＲＹ, 2002, ｖｏ．１, ｐｐ．５０３−５１４
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda