Title:
VLA-4アンタゴニスト
Document Type and Number:
Japanese Patent JP2007528397
Kind Code:
A
Abstract:
Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn's disease, multiple sclerosis, asthma, and rheumatoid arthritis.
Inventors:
William Kay, Hugman
Lin, Linus S
Liu pin
Mumphode, Lithiadee A
Lager, Thomas S
Smith, nicholas day
Stotsk, nicholas es
Zunitsk, Yasmine
Lin, Linus S
Liu pin
Mumphode, Lithiadee A
Lager, Thomas S
Smith, nicholas day
Stotsk, nicholas es
Zunitsk, Yasmine
Application Number:
JP2007502882A
Publication Date:
October 11, 2007
Filing Date:
March 07, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07K5/078; A61K38/00; A61P1/04; A61P7/06; A61P11/00; A61P11/06; A61P19/02; A61P25/00; A61P29/00; A61P35/02; A61P43/00; C07D401/12; C07D401/14
Foreign References:
| WO2002074761A1 | 2002-09-26 | |||
| US6583139B1 | 2003-06-24 | |||
| US20030008861A1 | 2003-01-09 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura