Title:
SIR2制御
Document Type and Number:
Japanese Patent JP2007535475
Kind Code:
A
Abstract:
Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screening for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.
Inventors:
Shram, Van El
Sowe, Anthony A.
Sowe, Anthony A.
Application Number:
JP2006518719A
Publication Date:
December 06, 2007
Filing Date:
June 30, 2004
Export Citation:
Assignee:
YESHIVA UNIVERSITY
International Classes:
A61K31/4409; A61K31/455; A61K38/00; A61P43/00; C07D213/81; C07D213/82; C07D213/83; C07D241/24; C12Q1/34; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Michiharu Soga
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku