Title:
4成分縮合反応による高分子コンジュゲートの調製
Document Type and Number:
Japanese Patent JP2008502788
Kind Code:
A
Abstract:
Polymer-biomolecule conjugates are prepared, generally in a site-specific or -selective manner, by a four-component condensation reaction. The method may be used to prepare conjugates having two polymer molecules attached at a single site on a biomolecule. The conjugates are typically water soluble and have beneficial pharmacological properties, such as reduced immunogenicity and increased circulation time.
Inventors:
The Lip Sky, Samuel
Application Number:
JP2007527690A
Publication Date:
January 31, 2008
Filing Date:
June 08, 2005
Export Citation:
Assignee:
Alza Corporation
International Classes:
C08G81/00; A61K31/728; A61K31/785; A61K38/00; A61K38/22; A61K38/46; A61K47/48; A61P7/06; C07K19/00; C08G65/329; C07K14/765; C07K14/78; C08B37/08
Domestic Patent References:
| JP2002500643A | 2002-01-08 | |||
| JPH0372469A | 1991-03-27 | |||
| JP2005146068A | 2005-06-09 | |||
| JP2000146971A | 2000-05-26 | |||
| JP2003535208A | 2003-11-25 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Kajiwara Saiko
Yukihiro Ikeda
Hajime Asamura
Kajiwara Saiko
Yukihiro Ikeda