Title:
HSP60のペプチド及びAPL型誘導体並びに医薬組成物
Document Type and Number:
Japanese Patent JP2008514553
Kind Code:
A
Abstract:
Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
Inventors:
Dominguez Orta, Maria, Del Carmen
Padron Palomares, Gabriel, Ramon
Lopez Marine, Nelia
Lorenzo Perez, Norairis
Barbera Betancourt, Ariana
Hernandez Garcia, Ariadna
Morella Cordoba, Vivian
Cosmetics, Karelia
Merino Garcia, Nelson, Scallop
Vasquez Bonacea, Ariel
Suarez Alba, Jose
Padron Palomares, Gabriel, Ramon
Lopez Marine, Nelia
Lorenzo Perez, Norairis
Barbera Betancourt, Ariana
Hernandez Garcia, Ariadna
Morella Cordoba, Vivian
Cosmetics, Karelia
Merino Garcia, Nelson, Scallop
Vasquez Bonacea, Ariel
Suarez Alba, Jose
Application Number:
JP2007532752A
Publication Date:
May 08, 2008
Filing Date:
September 22, 2005
Export Citation:
Assignee:
Centro in the Any Area Energy Biotechnology
International Classes:
C07K14/47; A61K38/00; A61P19/02; A61P29/00; A61P37/06; A61P37/08; A61P43/00
Domestic Patent References:
| JP2004501061A | 2004-01-15 |
Foreign References:
| WO1997011966A1 | 1997-04-03 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda