Title:
ピリダジン化合物、組成物および方法
Document Type and Number:
Japanese Patent JP2008518958
Kind Code:
A
Abstract:
The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
Compounds of Formula Ia or Ib
or
wherein R is a substituted amino group, R 2 is an unsaturated 5 to 6-membered heteromonocyclic group containing 1 to 4 nitrogen atoms, R 3 , R 4 , R 5 , and R 6 are hydrogen, and R 7 is absent; or a pharmaceutically acceptable salt thereof.
Inventors:
Watterson, Di. Martin
Van, Erdi Clinda
Esh, Jack
Ibert, Marcel
Bourguignon, Jean-Jack
Belenza, Anastasia
Hu, Wen Hui
The Sazkey, Magdalena
Van, Erdi Clinda
Esh, Jack
Ibert, Marcel
Bourguignon, Jean-Jack
Belenza, Anastasia
Hu, Wen Hui
The Sazkey, Magdalena
Application Number:
JP2007539305A
Publication Date:
June 05, 2008
Filing Date:
November 02, 2005
Export Citation:
Assignee:
Northwestern University
Universite Louis Pasteur de Strasbourg
Universite Louis Pasteur de Strasbourg
International Classes:
C07D237/20; A61K31/501; A61K31/506; A61K31/5377; A61P25/00; A61P25/28; A61P29/00; A61P43/00; C07D401/04; C07D401/14; C07D403/12
Domestic Patent References:
| JP2004510813A | 2004-04-08 | |||
| JPH04230380A | 1992-08-19 | |||
| JPS59212480A | 1984-12-01 | |||
| JP2001518908A | 2001-10-16 | |||
| JP2004510813A | 2004-04-08 | |||
| JPH04230380A | 1992-08-19 | |||
| JPS59212480A | 1984-12-01 | |||
| JP2001518908A | 2001-10-16 |
Foreign References:
| WO2004014891A1 | 2004-02-19 | |||
| WO1986006719A1 | 1986-11-20 | |||
| WO2003066604A2 | 2003-08-14 | |||
| WO2004014891A1 | 2004-02-19 | |||
| WO1986006719A1 | 1986-11-20 | |||
| WO2003066604A2 | 2003-08-14 |
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JPN6012011643; Ｊｕｒｇｅｎ Ｓａｕｅｒ ｅｔ ａｌ．: Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５４， Ｎｏ．１７, 1998, ｐ．４２９７-４３１２
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JPN6012011642; Ｔａｎｄｙ Ｌ． Ｄｒａｐｅｒ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６０， Ｎｏ．３, 1995, ｐ．７４８-７５０
JPN6012011643; Ｊｕｒｇｅｎ Ｓａｕｅｒ ｅｔ ａｌ．: Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５４， Ｎｏ．１７, 1998, ｐ．４２９７-４３１２
JPN6012011644; Ｆｌｏｒｅｎｃｅ Ｒｏｈｅｔ ｅｔ ａｌ．: Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５， Ｎｏ．４, 1997, ｐ．６５５-６５９
JPN6012011645; Ｙｖｅｌｉｎｅ Ｒｉｖａｌ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４１， Ｎｏ．３, 1998, ｐ．３１１-３１７
JPN6012011642; Ｔａｎｄｙ Ｌ． Ｄｒａｐｅｒ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６０， Ｎｏ．３, 1995, ｐ．７４８-７５０
JPN6012011643; Ｊｕｒｇｅｎ Ｓａｕｅｒ ｅｔ ａｌ．: Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５４， Ｎｏ．１７, 1998, ｐ．４２９７-４３１２
JPN6012011644; Ｆｌｏｒｅｎｃｅ Ｒｏｈｅｔ ｅｔ ａｌ．: Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５， Ｎｏ．４, 1997, ｐ．６５５-６５９
JPN6012011645; Ｙｖｅｌｉｎｅ Ｒｉｖａｌ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４１， Ｎｏ．３, 1998, ｐ．３１１-３１７
JPN6012011641; Ｍｉｃｈａｅｌ Ｓ． Ｓｏｕｔｈ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６１， Ｎｏ．２５, 1996, ｐ．８９２１-８９３４
JPN6012011642; Ｔａｎｄｙ Ｌ． Ｄｒａｐｅｒ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６０， Ｎｏ．３, 1995, ｐ．７４８-７５０
JPN6012011643; Ｊｕｒｇｅｎ Ｓａｕｅｒ ｅｔ ａｌ．: Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５４， Ｎｏ．１７, 1998, ｐ．４２９７-４３１２
JPN6012011644; Ｆｌｏｒｅｎｃｅ Ｒｏｈｅｔ ｅｔ ａｌ．: Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５， Ｎｏ．４, 1997, ｐ．６５５-６５９
JPN6012011645; Ｙｖｅｌｉｎｅ Ｒｉｖａｌ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４１， Ｎｏ．３, 1998, ｐ．３１１-３１７
Attorney, Agent or Firm:
Hidekazu Miyoshi
Masakazu Ito
Yuko Hara
Masakazu Ito
Yuko Hara