Title:
pH感受性のブロック共重合体及びこれを用いた高分子ミセル
Document Type and Number:
Japanese Patent JP2008520798
Kind Code:
A
Abstract:
Disclosed is a pH-sensitive block copolymer obtained by copolymerization of: (a) a polyethylene glycol compound (A); and (b) at least one poly(amino acid) compound selected from the group consisting of a poly(β-amino ester) and poly(amido amine) or a copolymer thereof (B). A method for preparing the same block copolymer, and a polymer micelle type drug composition comprising the pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The pH-sensitive block copolymer is obtained by polymerization of a hydrophilic polyethylene glycol compound with a pH-sensitive biodegradable poly(amino acid) compound. Therefore, the pH-sensitive block copolymer can form a micelle structure due to its amphiphilicity and ionization characteristics depending on pH variations, and thus can be used as drug carrier for target-directed drug delivery depending on pH variations in the body.
Inventors:
Do-Soon Lee
Min-San Kim
Soo-John Foong
John-Kwon Han
Bon-Suup Kim
Min-San Kim
Soo-John Foong
John-Kwon Han
Bon-Suup Kim
Application Number:
JP2007542928A
Publication Date:
June 19, 2008
Filing Date:
December 27, 2005
Export Citation:
Assignee:
Sung Kyun University Foundation for Corporate Collaboration
International Classes:
C08G81/00; A61K9/107; A61K47/34; C08G73/00
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro