Title:
3環性細胞保護化合物
Document Type and Number:
Japanese Patent JP2008528669
Kind Code:
A
Abstract:
Compounds of formula (I): [in which: X is a group of formula >CR1R2 or >SO2; Y is a group of formula >NH or >CR1R2; Z is a group of formula >C-O or >CH2 or a direct bond; R1 is hydrogen and R2 is hydrogen, carboxy or hydroxy; or R1 and R2 together represent an oxo group, a methylenedioxy group or a hydroxyimino group; R3 is hydrogen or lower alkyl; R4 represents two hydrogen atoms, or an oxo or hydroxyimino group; R5 is hydrogen, lower alkyl or halogen; R6 is hydrogen, lower alkoxy or carboxy; R7 and R8 are each hydrogen, lower alkyl or halogen; and pharmaceutically acceptable salts and esters thereof can be used for the treatment or prophylaxis of acute or chronic neurodegenerative diseases or conditions such as Alzheimer's Disease, Parkinson's Disease, Huntington's Chorea, Multiple Sclerosis or the sequelae to acute ischaemic events such as heart attack, stroke or head injury and for protection against ischaemic damage to tissues of peripheral organs.
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Inventors:
Würfeld, Ernst
Suckling, Colin James
Carafe, Ave Dawn Ibrahim
McKay, Simon Paul
Johnston, Blair Flasser
Suckling, Colin James
Carafe, Ave Dawn Ibrahim
McKay, Simon Paul
Johnston, Blair Flasser
Application Number:
JP2007553694A
Publication Date:
July 31, 2008
Filing Date:
February 02, 2006
Export Citation:
Assignee:
HUNTER-FLEMING LIMITED
International Classes:
C07D209/70; A61K31/403; A61K31/404; A61K31/407; A61P9/00; A61P9/10; A61P25/14; A61P25/16; A61P25/28; C07D209/82; C07D209/88; C07D491/10; C07D491/113; C07D495/04
Domestic Patent References:
| JPH04334367A | 1992-11-20 | |||
| JP2003507367A | 2003-02-25 |
Attorney, Agent or Firm:
Michiharu Soga
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku