Title:
リン酸アルミニウムおよび3D-MPLを含むアジュバント組成物
Document Type and Number:
Japanese Patent JP2008530195
Kind Code:
A
Abstract:
An immunogenic composition comprising: (i) an antigen; (ii) an aluminum phosphate adjuvant; and (iii) a 3-O-deacylated monophosphoryl lipid A adjuvant. Components (ii) and (iii) can also be used as a separate adjuvant system. Various features of the compositions are disclosed, including that at least 50% of the 3-O-deacylated monophosphoryl lipid A adjuvant should be adsorbed to the aluminum phosphate adjuvant. The adjuvant mixture is particularly useful with hepatitis B virus surface antigen.
Inventors:
O'Hagan, Dillek
Application Number:
JP2007555701A
Publication Date:
August 07, 2008
Filing Date:
February 16, 2006
Export Citation:
Assignee:
Novartis Vaxins And Diagnostics, Incorporated
International Classes:
A61K39/39; A61K39/29; A61P1/16; A61P31/20
Foreign References:
| WO2000023105A2 | 2000-04-27 | |||
| WO1996026741A1 | 1996-09-06 | |||
| WO2000023574A2 | 2000-04-27 | |||
| US20010053365A1 | 2001-12-20 | |||
| WO2001017551A2 | 2001-03-15 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita