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Patent Searching and Data


Title:
選択的なグリコシダーゼインヒビター、インヒビターを作製する方法、およびインヒビターの使用
Document Type and Number:
Japanese Patent JP2008531604
Kind Code:
A
Abstract:
The invention comprises compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions containing the compounds or prodrugs of the compounds. The invention also comprises animal models and methods of making the animal models for studying diseases and disorders related to deficiency or overexpression of O-GIcNAcase, accumulation or deficiency of O-GIcNAc, and treatment of such diseases and disorders. The invention also comprises methods of treating such diseases and disorders. The invention also comprises methods of making the compounds, and methods of making selective glycosidase inhibitors.

Inventors:
ボカドロ, デイビッド
ホイットウォース, ギャレット
マコーリー, マシュー
Application Number:
JP2007557300A
Publication Date:
August 14, 2008
Filing Date:
March 01, 2006
Export Citation:
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Assignee:
サイモン フレイザー ユニバーシティ
International Classes:
C07H9/00; A61K31/351; A61K31/7042; A61P3/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00; C07D309/30; C07H13/06
Foreign References:
WO2004103368A12004-12-02
Other References:
JPN7012000526; Diabetes Vol.53, No.4, 2004, 921-930
JPN7012000527; Proceedings of the National Academy of Sciences of the United States of America Vol.99, No.8, 2002, 5313-5318
JPN6012007271; Helvetica Chimica Acta Vol.83, No.1, 2000, p.114-118
JPN7012000526; Diabetes Vol.53, No.4, 2004, 921-930
JPN7012000527; Proceedings of the National Academy of Sciences of the United States of America Vol.99, No.8, 2002, 5313-5318
Attorney, Agent or Firm:
山本 秀策
安村 高明
森下 夏樹