選択的なグリコシダーゼインヒビター、インヒビターを作製する方法、およびインヒビターの使用

Japanese Patent JP2008531604

A

The invention comprises compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions containing the compounds or prodrugs of the compounds. The invention also comprises animal models and methods of making the animal models for studying diseases and disorders related to deficiency or overexpression of O-GIcNAcase, accumulation or deficiency of O-GIcNAc, and treatment of such diseases and disorders. The invention also comprises methods of treating such diseases and disorders. The invention also comprises methods of making the compounds, and methods of making selective glycosidase inhibitors.

WO1999061456	SUCROSE-BASED SURFACTANTS AND METHODS THEREFOR
WO/2003/070738	TOPIRAMATE SALTS AND COMPOSITIONS COMPRISING AND METHODS OF MAKING AND USING THE SAME
JP4504018	Manufacture and use of carbohydrate-based bicyclic ring structures with antibacterial and cell growth inhibitory activity

David Vocaloid
Whitworth, Garrett
Macquarie, Matthew

JP2007557300A

August 14, 2008

March 01, 2006

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Simon Fraser University

C07H9/00; A61K31/351; A61K31/7042; A61P3/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00; C07D309/30; C07H13/06

WO2004103368A1

2004-12-02

JPN7012000526; Ｄｉａｂｅｔｅｓ Ｖｏｌ．５３，　Ｎｏ．４, 2004, ９２１-９３０
JPN7012000527; Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｎａｔｉｏｎａｌ　Ａｃａｄｅｍｙ　ｏｆ　Ｓｃｉｅｎｃｅｓ　ｏｆ　ｔｈｅ　Ｕｎｉｔｅｄ　Ｓｔａｔｅｓ　ｏｆ　Ａｍｅｒｉｃａ Ｖｏｌ．９９，　Ｎｏ．８, 2002, ５３１３-５３１８
JPN6012007271; Ｈｅｌｖｅｔｉｃａ　Ｃｈｉｍｉｃａ　Ａｃｔａ Ｖｏｌ．８３，　Ｎｏ．１, 2000, ｐ．１１４-１１８
JPN7012000526; Ｄｉａｂｅｔｅｓ Ｖｏｌ．５３，　Ｎｏ．４, 2004, ９２１-９３０
JPN7012000527; Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｎａｔｉｏｎａｌ　Ａｃａｄｅｍｙ　ｏｆ　Ｓｃｉｅｎｃｅｓ　ｏｆ　ｔｈｅ　Ｕｎｉｔｅｄ　Ｓｔａｔｅｓ　ｏｆ　Ａｍｅｒｉｃａ Ｖｏｌ．９９，　Ｎｏ．８, 2002, ５３１３-５３１８

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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