Title:
放射性同位体で標識された生物学的組成物、および加速器質量分析法におけるその使用
Document Type and Number:
Japanese Patent JP2008531670
Kind Code:
A
Abstract:
The invention provides a biological composition comprising a biological compound of formula I B-A* (I) alone or together with B wherein B-A* is a biological compound or a derivative thereof formed as the product of reaction of the biological compound to introduce A*, A* is a radioisotopic moiety having MW in the range 10 to 500 comprising an AMS radioisotope * wherein the composition is characterised by a value for the percent incorporation of radioisotope which is a measure of maximum specific activity, wherein 100% incorporation is defined as the incorporation of one radioisotope per molecule, and wherein the percent incorporation is in the range from in excess of zero to 100%, wherein the quantity of organic radioisotope A* labelled molecules in a population of one thousand molecules is so low as to not alter the biological activity of the drug; a process for the preparation thereof; a method for AMS detection of one or more biological compositions as defined in any of claims 1 to 17 comprising B of same or different origin, comprising providing one or more biological compositions and optionally one or more control compositions comprising biological compound B, for dosing to at least one subject, obtaining metabolic samples from the subject(s) having been dosed with said biological(s) as hereinbefore defined and conducting AMS detection and obtaining AMS results for the or each biological; and the use of a biological composition or compound of formula I in AMS detection providing in vitro or in vivo metabolism characteristics thereof.
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Inventors:
Ronald Colin, Garner
Rappin, Graham John
Rappin, Graham John
Application Number:
JP2007557579A
Publication Date:
August 14, 2008
Filing Date:
February 28, 2006
Export Citation:
Assignee:
Exceleron Limited
International Classes:
C07K14/765; A61K51/08; C07K1/02; G01N27/62; G01N33/60
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita