Title:
末梢神経毒症状を処置するためのADNFポリペプチドの使用
Document Type and Number:
Japanese Patent JP2008535805
Kind Code:
A
Abstract:
This invention relates to the use of ADNF polypeptides in the treatment of neurotoxicity induced by chemical agents or by disease processes. The ADNF polypeptides include ADNF I and ADNF III (also referred to as ADNP) polypeptides, analogs, subsequences such as NAP and SAL, and D-amino acid versions (either wholly D-amino acid peptides or mixed D- and L-amino acid peptides), and combinations thereof which contain their respective active core sites.
Inventors:
Gozes Ilana
Mirror james
Mirror james
Application Number:
JP2008502205A
Publication Date:
September 04, 2008
Filing Date:
March 23, 2006
Export Citation:
Assignee:
Ramoto at Telu Aviv University Limited
Aron Therapeutics, Inc.
Aron Therapeutics, Inc.
International Classes:
A61K38/00; A61K45/00; A61P3/10; A61P9/10; A61P13/12; A61P21/00; A61P25/02; A61P25/28; A61P25/32; A61P31/04; A61P31/08; A61P31/12; A61P31/14; A61P35/00; C07K7/06; C07K7/08; C07K14/47
Domestic Patent References:
| JP2001522228A | 2001-11-13 | |||
| JP2001522228A | 2001-11-13 |
Foreign References:
| WO2001012654A2 | 2001-02-22 | |||
| US20030166544A1 | 2003-09-04 | |||
| WO2000027875A2 | 2000-05-18 |
Other References:
JPN6011048417; ＬＡＧＲＥＺＥ，Ｗ．Ａ． ｅｔ ａｌ: 'Ｔｈｅ ｐｅｐｔｉｄｅｓ ＡＤＮＦ-９ ａｎｄ ＮＡＰ ｉｎｃｒｅａｓｅ ｓｕｒｖｉｖａｌ ａｎｄ ｎｅｕｒｉｔｅ ｏｕｔｇｒｏｗｔｈ ｏｆ ｒａｔ ｒｅｔｉｎａｌ ｇａｎｇｌｉｏｎ ｃｅｌｌｓ ｉｎ' Ｉｎｖｅｓｔ Ｏｐｈｔｈａｌｍｏｌ Ｖｉｓ Ｓｃｉ Ｖｏｌ．４６， Ｎｏ．３, 2005, ｐ．９３３-８
JPN6011048420; ＣＨＩＢＡ，Ｔ． ｅｔ ａｌ: 'Ｎｅｕｒｏｐｒｏｔｅｃｔｉｖｅ ｅｆｆｅｃｔ ｏｆ ａｃｔｉｖｉｔｙ-ｄｅｐｅｎｄｅｎｔ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔｏｒ ａｇａｉｎｓｔ ｔｏｘｉｃｉｔｙ ｆｒｏｍ ｆａｍｉｌｉａｌ ａｍｙｏ' Ｊ Ｎｅｕｒｏｓｃｉ Ｒｅｓ Ｖｏｌ．７８， Ｎｏ．４, 2004, ｐ．５４２-５２
JPN6012041038; ＧＯＺＥＳ，Ｉ． ｅｔ ａｌ: 'Ａｎｔｉｓｅｒｕｍ ｔｏ ａｃｔｉｖｉｔｙ-ｄｅｐｅｎｄｅｎｔ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔｏｒ ｐｒｏｄｕｃｅｓ ｎｅｕｒｏｎａｌ ｃｅｌｌ ｄｅａｔｈ ｉｎ ＣＮＳ ｃｕｌｔｕｒｅｓ： ｉｍ' Ｂｒａｉｎ Ｒｅｓ Ｄｅｖ Ｂｒａｉｎ Ｒｅｓ Ｖｏｌ．９９， Ｎｏ．２, 1997, ｐ．１６７-７５
JPN6011048420; ＣＨＩＢＡ，Ｔ． ｅｔ ａｌ: 'Ｎｅｕｒｏｐｒｏｔｅｃｔｉｖｅ ｅｆｆｅｃｔ ｏｆ ａｃｔｉｖｉｔｙ-ｄｅｐｅｎｄｅｎｔ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔｏｒ ａｇａｉｎｓｔ ｔｏｘｉｃｉｔｙ ｆｒｏｍ ｆａｍｉｌｉａｌ ａｍｙｏ' Ｊ Ｎｅｕｒｏｓｃｉ Ｒｅｓ Ｖｏｌ．７８， Ｎｏ．４, 2004, ｐ．５４２-５２
JPN6012041038; ＧＯＺＥＳ，Ｉ． ｅｔ ａｌ: 'Ａｎｔｉｓｅｒｕｍ ｔｏ ａｃｔｉｖｉｔｙ-ｄｅｐｅｎｄｅｎｔ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔｏｒ ｐｒｏｄｕｃｅｓ ｎｅｕｒｏｎａｌ ｃｅｌｌ ｄｅａｔｈ ｉｎ ＣＮＳ ｃｕｌｔｕｒｅｓ： ｉｍ' Ｂｒａｉｎ Ｒｅｓ Ｄｅｖ Ｂｒａｉｎ Ｒｅｓ Ｖｏｌ．９９， Ｎｏ．２, 1997, ｐ．１６７-７５
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue