Title:
心不全における遺伝リスク、すなわちNOS3の遺伝子変異の影響の評価方法
Document Type and Number:
Japanese Patent JP2008535858
Kind Code:
A
Abstract:
The invention provides methods for (a) reducing mortality associated with heart failure; (b) improving oxygen consumption; (c) treating heart failure; (d) treating hypertension; (e) improving the quality of life in a heart failure patient; (f) inhibiting left ventricular remodeling; (g) reducing hospitalizations related to heart failure; (h) improving exercise tolerance; (j) increasing left ventricular ejection fraction; (k) decreasing levels of B-type natriuretic protein; (l) treating renovascular diseases; (m) treating end-stage renal diseases; (n) reducing cardiomegaly; (o) treating diseases resulting from oxidative stress; (p) treating endothelial dysfunctions; (q) treating diseases caused by endothelial dysfunctions; (r) treating cardiovascular diseases; in a patient in need thereof, wherein the patient has at least one polymorphism in the endothelial nitric oxide synthase (NOS3) gene, comprising administering to the patient (i) at least one antioxidant compound or a pharmaceutically acceptable salt thereof; (ii) at least one nitric oxide enhancing compound; and (iii) optionally the best current therapy for the treatment of cardiovascular diseases. In one embodiment the antioxidant is a hydralazine compound or a pharmaceutically acceptable salt thereof and the nitric oxide enhancing compound is isosorbide dinitrate and/or isosorbide mononitrate.
Inventors:
Worsell Manuel
Savorinski michael
Tamsun W.
McNamara Denise M.
Savorinski michael
Tamsun W.
McNamara Denise M.
Application Number:
JP2008505611A
Publication Date:
September 04, 2008
Filing Date:
April 07, 2006
Export Citation:
Assignee:
Nitromed Incorporated
University of Pittsburgh of the Commonwealth System of Higher Education
University of Pittsburgh of the Commonwealth System of Higher Education
International Classes:
A61K45/06; A61K31/138; A61K31/341; A61K31/401; A61K31/502; A61K31/585; A61K38/55; A61P3/06; A61P5/18; A61P7/02; A61P7/10; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P19/02; A61P25/28; A61P29/00; A61P31/04; A61P35/00; A61P39/02; A61P39/06; A61P43/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue