Title:
生体強化組成物
Document Type and Number:
Japanese Patent JP2008536929
Kind Code:
A
Abstract:
The present invention relates to the method of increasing the bioavailability of Angiotensin II Receptor Blockers (ARBs) by preparing a composition of an ARB with at least one solubility enhancing agent. In particular, the present invention relates to solubility enhancing agents that not only act as solubility enhancers but also improve the dissolution rate particularly in acidic or mildly acidic media, where solubility of the ARB is minimal. In the composition, the ARB may be present in the form of physical blend, solid dispersion, solid solution or complex with the solubility enhancing agent. The composition of an ARB with solubility enhancing agent can be incorporated in an immediate release or a controlled release or any other suitable modified release formulation. Immediate release dosage forms containing the composition of an ARB give an in vitro release of at least 40% in acidic media (pH < 3). As a result, the bioavailability of the ARB can be increased by at least 20% as measured by Cmax, AUC0-t and AUCo-8.
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Inventors:
Nagesh Earl Palape
Plativa es pilga onker
Mahaluk Rustmusie
Anil Kumar S Gandhi
Pallas Earl Jane
Plativa es pilga onker
Mahaluk Rustmusie
Anil Kumar S Gandhi
Pallas Earl Jane
Application Number:
JP2008507777A
Publication Date:
September 11, 2008
Filing Date:
April 18, 2006
Export Citation:
Assignee:
Rubycon Research Pvt. Ltd.
International Classes:
A61K31/41; A61K9/20; A61K9/48; A61K31/4178; A61K31/4184; A61K45/00; A61K47/04; A61K47/10; A61K47/14; A61K47/20; A61K47/22; A61K47/26; A61K47/32; A61K47/34; A61K47/38; A61K47/40; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P17/00; A61P25/22; A61P25/24; A61P25/28
Domestic Patent References:
| JP2004002348A | 2004-01-08 | |||
| JP2006511542A | 2006-04-06 |
Foreign References:
| WO2004105694A2 | 2004-12-09 |
Other References:
JPN6012012126; 医薬品添付文書（ディオバン錠） 第６版, 2003
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro