Title:
医薬化合物
Document Type and Number:
Japanese Patent JP2008538750
Kind Code:
A
Abstract:
The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R 1 is hydroxy or hydrogen; R 2 is hydroxy; methoxy or hydrogen; provided that at least one of R 1 and R 2 is hydroxy; R 3 is selected from hydrogen; halogen; cyano; optionally substituted C 1-5 hydrocarbyl and optionally substituted C 1-5 hydrocarbyloxy; R 4 is selected from hydrogen; a group -(O) n -R 7 where n is 0 or 1 and R 7 is an optionally substituted acyclic C 1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C 1-5 hydrocarbylamino; or R 3 and R 4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR 5 R 6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.
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Inventors:
Jani, Cessari
Miles, Stuart, Congreave
Eve, Figueroa, Navallo
Martin, Frederickson
Christopher, Murray
Allison, Joe-Ann, Wolford
Maria, Grazia, Carl
Michael, Alistair, O'Brien
Andrew, James, Woodhead
Miles, Stuart, Congreave
Eve, Figueroa, Navallo
Martin, Frederickson
Christopher, Murray
Allison, Joe-Ann, Wolford
Maria, Grazia, Carl
Michael, Alistair, O'Brien
Andrew, James, Woodhead
Application Number:
JP2008505961A
Publication Date:
November 06, 2008
Filing Date:
April 13, 2006
Export Citation:
Assignee:
ASTEX THERAPEUTICS LIMITED
International Classes:
C07C235/60; A61K31/166; A61K31/167; A61K31/351; A61K31/40; A61K31/445; A61K31/45; A61K31/495; A61K31/496; A61K31/4965; A61K31/5375; A61K31/54; A61K31/553; A61P35/00; C07C235/46; C07D207/06; C07D207/08; C07D207/12; C07D207/16; C07D211/22; C07D211/26; C07D211/34; C07D211/42; C07D211/44; C07D211/52; C07D211/56; C07D211/60; C07D213/74; C07D241/08; C07D265/30; C07D267/10; C07D279/12; C07D295/08; C07D295/10; C07D295/14; C07D295/18; C07D307/14; C07D309/14
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota