Title:
骨の形成および保存を促進するための方法
Document Type and Number:
Japanese Patent JP2008540522
Kind Code:
A
Abstract:
A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.
Inventors:
Bignery, Agnes
Meter, North M
Gilligan, James Py
Meter, North M
Gilligan, James Py
Application Number:
JP2008511101A
Publication Date:
November 20, 2008
Filing Date:
November 07, 2005
Export Citation:
Assignee:
Unigene Laboratories, Inc.
International Classes:
A61K45/00; A61K38/22; A61K38/23; A61P19/08
Domestic Patent References:
| JP2002523375A | 2002-07-30 |
Attorney, Agent or Firm:
Kuro Fukami
Toshio Morita
Yoshihei Nakamura
Yutaka Horii
Hisato Noda
Masayuki Sakai
Nobuo Arakawa
Toshio Morita
Yoshihei Nakamura
Yutaka Horii
Hisato Noda
Masayuki Sakai
Nobuo Arakawa