第Xa因子阻害剤としてのヘテロアリール-カルボン酸(スルファモイルアルキル)アミド-誘導体

Japanese Patent JP2008540589

A

The present invention relates to compounds of the formula I, in which R1; R2; R3; V; G1 and G2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa, and can in general be applied in conditions in which an undesired activity of factor Xa is present or for the cure or prevention of which an inhibition of factor Xa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

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Michael Wagner
Matthias Wooman
Volkmar Weener
Martin Lorenz
Armin Bauer
Marc Nazareth
Hans Matter

JP2008511587A

November 20, 2008

May 06, 2006

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Sanofi-Aventis

C07D409/12; A61K31/445; A61K31/4525; A61K31/4535; A61K31/454; A61K31/4545; A61K31/496; A61K31/5377; A61K31/541; A61P7/02; A61P9/00; A61P9/10; A61P9/14; A61P11/00; A61P29/00; A61P31/12; A61P35/00; C07D211/54; C07D333/38; C07D401/12; C07D405/12; C07D409/14; C07D413/12; C07D413/14; C07D417/14; C07D419/14

WO2004056815A1	2004-07-08
WO2004101557A1	2004-11-25
WO2004046138A1	2004-06-03
WO2002060894A2	2002-08-08
WO2002051831A1	2002-07-04

Chika Takagi
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi

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