Title:
アミノキノリンおよびアミノキナゾリンキナーゼモジュレーター
Document Type and Number:
Japanese Patent JP2008543762
Kind Code:
A
Abstract:
The invention is directed to aminoquinoline and aminoquinazoline compounds of Formula I: where R1, R2, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
Inventors:
Binder, nando
Goal, michael david
Creator, Kevin Douglas
Bowman, Christian Andreux
Sue, Guo Tuang
Kim, Alexander Jei
Tuao, Bao-ping
Goal, michael david
Creator, Kevin Douglas
Bowman, Christian Andreux
Sue, Guo Tuang
Kim, Alexander Jei
Tuao, Bao-ping
Application Number:
JP2008515893A
Publication Date:
December 04, 2008
Filing Date:
June 07, 2006
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D401/04; A61K31/4709; A61K31/517; A61K31/5377; A61P35/00; A61P43/00; C07D401/14; C07D403/04; C07D403/14
Attorney, Agent or Firm:
Patent business corporation Odashima patent office
Heikichi Odashima
Heikichi Odashima