Title:
神経保護効果のある化合物
Document Type and Number:
Japanese Patent JP2009506982
Kind Code:
A
Abstract:
The present application discloses a method of preventing degeneration of nerve, which includes: a) generating a recombinant viral or plasmid vector comprising a DNA sequence encoding a member of a transforming growth factor superfamily or neurotrophic factor proteins operatively linked to a promoter; b) transfecting in vitro a population of cultured cells with the recombinant vector, resulting in a population of the cultured cells; and c) transplanting the transfected cells to an area near an injured nerve, such that expression of the DNA sequence within the area near the injured nerve causes prevention of degeneration of the nerve.
Inventors:
Li, Kwan, Hi
Lee, Duk, Coins
Lee, Yang Su
Now, Moon, John
Kim, Hyun, Chiyun
Lee, Duk, Coins
Lee, Yang Su
Now, Moon, John
Kim, Hyun, Chiyun
Application Number:
JP2008518473A
Publication Date:
February 19, 2009
Filing Date:
June 23, 2006
Export Citation:
Assignee:
Tissue gene, ink
International Classes:
A61K38/00; A61K35/12; A61K35/76; A61K48/00; A61P25/00; C12N15/09
Domestic Patent References:
| JP2004525070A | 2004-08-19 | |||
| JP2005514408A | 2005-05-19 | |||
| JP2003508493A | 2003-03-04 | |||
| JPH09501932A | 1997-02-25 | |||
| JPH09151132A | 1997-06-10 | |||
| JP2003508493A | 2003-03-04 | |||
| JP2001517634A | 2001-10-09 |
Foreign References:
| WO1996025929A1 | 1996-08-29 | |||
| WO2002007749A2 | 2002-01-31 | |||
| WO2003082302A2 | 2003-10-09 |
Other References:
JPN6011059372; ＷＩＮＮ，Ｓ．Ｒ． ｅｔ ａｌ: 'Ｐｏｌｙｍｅｒ-ｅｎｃａｐｓｕｌａｔｅｄ ｃｅｌｌｓ ｇｅｎｅｔｉｃａｌｌｙ ｍｏｄｉｆｉｅｄ ｔｏ ｓｅｃｒｅｔｅ ｈｕｍａｎ ｎｅｒｖｅ ｇｒｏｗｔｈ ｆａｃｔｏｒ ｐｒｏｍｏｔｅ ｔｈｅ ｓｕｒ' Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ Ｕ Ｓ Ａ Ｖｏｌ．９１， Ｎｏ．６, 1994, ｐ．２３２４-８
JPN6011059370; ＴＵＳＺＹＮＳＫＩ，Ｍ．Ｈ．: 'Ｇｒｏｗｔｈ-ｆａｃｔｏｒ ｇｅｎｅ ｔｈｅｒａｐｙ ｆｏｒ ｎｅｕｒｏｄｅｇｅｎｅｒａｔｉｖｅ ｄｉｓｏｒｄｅｒｓ' Ｌａｎｃｅｔ Ｎｅｕｒｏｌ Ｖｏｌ．１， Ｎｏ．１, 2002, ｐ．５１-７
JPN5008009193; ＬＡＷＲＥＮＣＥ， Ｊ．Ｍ．: 'Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ ｏｆ Ｓｃｈｗａｎｎ ｃｅｌｌ ｌｉｎｅ ｃｌｏｎｅｓ ｓｅｃｒｅｔｉｎｇ ＧＤＮＦ ｏｒ ＢＤＮＦ ｉｎｔｏ ｔｈｅ ｒｅｔｉｎａｓ ｏｆ ｄｙｓｔｒｏｐｈｉｃ Ｒｏ' ＩＮＶＥＳＴ． ＯＰＨＴＨＡＬＭＡＬ． ＶＩＳ． ＳＣＩ． Ｖ４５ Ｎ１, 200401, Ｐ２６７-２７４
JPN6011059371; ＴＨＯＭＡＤＡＫＩＳ，Ｇ． ｅｔ ａｌ: 'Ｉｍｍｕｎｏｌｏｃａｌｉｚａｔｉｏｎ ｏｆ Ｂｏｎｅ Ｍｏｒｐｈｏｇｅｎｅｔｉｃ Ｐｒｏｔｅｉｎ-２ ａｎｄ -３ ａｎｄ Ｏｓｔｅｏｇｅｎｉｃ Ｐｒｏｔｅｉｎ-１ ｄｕｒｉｎｇ ｍｕｒｉｎｅ ｔｏｏ' Ｅｕｒ Ｊ Ｏｒａｌ Ｓｃｉ Ｖｏｌ．１０７， Ｎｏ．５, 1999, ｐ．３６８-７７
JPN6012048129; ＨＡＲＶＥＹ，Ｂ．Ｋ． ｅｔ ａｌ: 'Ｎｅｕｒｏｔｒｏｐｈｉｃ ｅｆｆｅｃｔｓ ｏｆ ｂｏｎｅ ｍｏｒｐｈｏｇｅｎｅｔｉｃ ｐｒｏｔｅｉｎ-７ ｉｎ ａ ｒａｔ ｍｏｄｅｌ ｏｆ Ｐａｒｋｉｎｓｏｎ'ｓ ｄｉｓｅａｓｅ' Ｂｒａｉｎ Ｒｅｓ Ｖｏｌ．１０２２， Ｎｏ．１-２, 2004, ｐ．８８-９５
JPN6012048126; ＲＥＩＲＩＺ，Ｊ． ｅｔ ａｌ: 'ＢＭＰ-２ ａｎｄ ｃＡＭＰ ｅｌｅｖａｔｉｏｎ ｃｏｎｆｅｒ ｌｏｃｕｓ ｃｏｅｒｕｌｅｕｓ ｎｅｕｒｏｎｓ ｒｅｓｐｏｎｓｉｖｅｎｅｓｓ ｔｏ ｍｕｌｔｉｐｌｅ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔ' Ｊ Ｎｅｕｒｏｂｉｏｌ Ｖｏｌ．５０， Ｎｏ．４, 2002, ｐ．２９１-３０４
JPN6012048127; ＥＳＰＥＪＯ，Ｍ． ｅｔ ａｌ: 'Ｅｘｐｏｓｕｒｅ ｏｆ ｆｏｅｔａｌ ｍｅｓｅｎｃｅｐｈａｌｉｃ ｃｅｌｌｓ ｔｏ ｂｏｎｅ ｍｏｒｐｈｏｇｅｎｅｔｉｃ ｐｒｏｔｅｉｎ-２ ｅｎｈａｎｃｅｓ ｔｈｅ ｓｕｒｖｉｖａｌ ｏｆ ｄｏｐａ' Ｎｅｕｒｏｓｃｉ Ｌｅｔｔ Ｖｏｌ．２７５， Ｎｏ．１, 1999, ｐ．１３-６
JPN6012048131; ＺＨＥＮＧ，Ｊ．Ｓ． ｅｔ ａｌ: 'Ｄｅｌａｙｅｄ ｇｅｎｅ ｔｈｅｒａｐｙ ｏｆ ｇｌｉａｌ ｃｅｌｌ ｌｉｎｅ-ｄｅｒｉｖｅｄ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔｏｒ ｉｓ ｅｆｆｉｃａｃｉｏｕｓ ｉｎ ａ ｒａｔ ｍｏｄｅｌ ｏｆ' Ｂｒａｉｎ Ｒｅｓ Ｍｏｌ Ｂｒａｉｎ Ｒｅｓ Ｖｏｌ．１３４， Ｎｏ．１, 2005, ｐ．１５５-６１
JPN6012048133; ＳＡＩＴＯ，Ｋ． ｅｔ ａｌ: 'Ａｄｅｎｏｖｉｒａｌ ＧＤＮＦ ｇｅｎｅ ｔｒａｎｓｆｅｒ ｐｒｅｖｅｎｔｓ ｍｏｔｏｎｅｕｒｏｎ ｌｏｓｓ ｉｎ ｔｈｅ ｎｕｃｌｅｕｓ ａｍｂｉｇｕｕｓ' Ｂｒａｉｎ Ｒｅｓ Ｖｏｌ．９６２， Ｎｏ．１-２, 2003, ｐ．６１-７
JPN6013045073; Ｍａｒｔｉｎ Ｄ．， ｅｔ ａｌ．: 'Ｐｏｔｅｎｔ ｉｎｈｉｂｉｔｏｒｙ ｅｆｆｅｃｔｓ ｏｆ ｇｌｉａｌ ｄｅｒｉｖｅｄ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔｏｒ ａｇａｉｎｓｔ ｋａｉｎｉｃ ａｃｉｄ ｍｅｄｉａｔｅｄ ｓｅｉｚｕｒｅｓ' Ｂｒａｉｎ Ｒｅｓ． ６８３（２）, 1995, １７２-８
JPN6011059370; ＴＵＳＺＹＮＳＫＩ，Ｍ．Ｈ．: 'Ｇｒｏｗｔｈ-ｆａｃｔｏｒ ｇｅｎｅ ｔｈｅｒａｐｙ ｆｏｒ ｎｅｕｒｏｄｅｇｅｎｅｒａｔｉｖｅ ｄｉｓｏｒｄｅｒｓ' Ｌａｎｃｅｔ Ｎｅｕｒｏｌ Ｖｏｌ．１， Ｎｏ．１, 2002, ｐ．５１-７
JPN5008009193; ＬＡＷＲＥＮＣＥ， Ｊ．Ｍ．: 'Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ ｏｆ Ｓｃｈｗａｎｎ ｃｅｌｌ ｌｉｎｅ ｃｌｏｎｅｓ ｓｅｃｒｅｔｉｎｇ ＧＤＮＦ ｏｒ ＢＤＮＦ ｉｎｔｏ ｔｈｅ ｒｅｔｉｎａｓ ｏｆ ｄｙｓｔｒｏｐｈｉｃ Ｒｏ' ＩＮＶＥＳＴ． ＯＰＨＴＨＡＬＭＡＬ． ＶＩＳ． ＳＣＩ． Ｖ４５ Ｎ１, 200401, Ｐ２６７-２７４
JPN6011059371; ＴＨＯＭＡＤＡＫＩＳ，Ｇ． ｅｔ ａｌ: 'Ｉｍｍｕｎｏｌｏｃａｌｉｚａｔｉｏｎ ｏｆ Ｂｏｎｅ Ｍｏｒｐｈｏｇｅｎｅｔｉｃ Ｐｒｏｔｅｉｎ-２ ａｎｄ -３ ａｎｄ Ｏｓｔｅｏｇｅｎｉｃ Ｐｒｏｔｅｉｎ-１ ｄｕｒｉｎｇ ｍｕｒｉｎｅ ｔｏｏ' Ｅｕｒ Ｊ Ｏｒａｌ Ｓｃｉ Ｖｏｌ．１０７， Ｎｏ．５, 1999, ｐ．３６８-７７
JPN6012048129; ＨＡＲＶＥＹ，Ｂ．Ｋ． ｅｔ ａｌ: 'Ｎｅｕｒｏｔｒｏｐｈｉｃ ｅｆｆｅｃｔｓ ｏｆ ｂｏｎｅ ｍｏｒｐｈｏｇｅｎｅｔｉｃ ｐｒｏｔｅｉｎ-７ ｉｎ ａ ｒａｔ ｍｏｄｅｌ ｏｆ Ｐａｒｋｉｎｓｏｎ'ｓ ｄｉｓｅａｓｅ' Ｂｒａｉｎ Ｒｅｓ Ｖｏｌ．１０２２， Ｎｏ．１-２, 2004, ｐ．８８-９５
JPN6012048126; ＲＥＩＲＩＺ，Ｊ． ｅｔ ａｌ: 'ＢＭＰ-２ ａｎｄ ｃＡＭＰ ｅｌｅｖａｔｉｏｎ ｃｏｎｆｅｒ ｌｏｃｕｓ ｃｏｅｒｕｌｅｕｓ ｎｅｕｒｏｎｓ ｒｅｓｐｏｎｓｉｖｅｎｅｓｓ ｔｏ ｍｕｌｔｉｐｌｅ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔ' Ｊ Ｎｅｕｒｏｂｉｏｌ Ｖｏｌ．５０， Ｎｏ．４, 2002, ｐ．２９１-３０４
JPN6012048127; ＥＳＰＥＪＯ，Ｍ． ｅｔ ａｌ: 'Ｅｘｐｏｓｕｒｅ ｏｆ ｆｏｅｔａｌ ｍｅｓｅｎｃｅｐｈａｌｉｃ ｃｅｌｌｓ ｔｏ ｂｏｎｅ ｍｏｒｐｈｏｇｅｎｅｔｉｃ ｐｒｏｔｅｉｎ-２ ｅｎｈａｎｃｅｓ ｔｈｅ ｓｕｒｖｉｖａｌ ｏｆ ｄｏｐａ' Ｎｅｕｒｏｓｃｉ Ｌｅｔｔ Ｖｏｌ．２７５， Ｎｏ．１, 1999, ｐ．１３-６
JPN6012048131; ＺＨＥＮＧ，Ｊ．Ｓ． ｅｔ ａｌ: 'Ｄｅｌａｙｅｄ ｇｅｎｅ ｔｈｅｒａｐｙ ｏｆ ｇｌｉａｌ ｃｅｌｌ ｌｉｎｅ-ｄｅｒｉｖｅｄ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔｏｒ ｉｓ ｅｆｆｉｃａｃｉｏｕｓ ｉｎ ａ ｒａｔ ｍｏｄｅｌ ｏｆ' Ｂｒａｉｎ Ｒｅｓ Ｍｏｌ Ｂｒａｉｎ Ｒｅｓ Ｖｏｌ．１３４， Ｎｏ．１, 2005, ｐ．１５５-６１
JPN6012048133; ＳＡＩＴＯ，Ｋ． ｅｔ ａｌ: 'Ａｄｅｎｏｖｉｒａｌ ＧＤＮＦ ｇｅｎｅ ｔｒａｎｓｆｅｒ ｐｒｅｖｅｎｔｓ ｍｏｔｏｎｅｕｒｏｎ ｌｏｓｓ ｉｎ ｔｈｅ ｎｕｃｌｅｕｓ ａｍｂｉｇｕｕｓ' Ｂｒａｉｎ Ｒｅｓ Ｖｏｌ．９６２， Ｎｏ．１-２, 2003, ｐ．６１-７
JPN6013045073; Ｍａｒｔｉｎ Ｄ．， ｅｔ ａｌ．: 'Ｐｏｔｅｎｔ ｉｎｈｉｂｉｔｏｒｙ ｅｆｆｅｃｔｓ ｏｆ ｇｌｉａｌ ｄｅｒｉｖｅｄ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔｏｒ ａｇａｉｎｓｔ ｋａｉｎｉｃ ａｃｉｄ ｍｅｄｉａｔｅｄ ｓｅｉｚｕｒｅｓ' Ｂｒａｉｎ Ｒｅｓ． ６８３（２）, 1995, １７２-８
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga
Yuriko Shinobu
Takuya Osugi
Aki Soga