Title:
ジピペラジニルケトンおよび関連する類似体
Document Type and Number:
Japanese Patent JP2009506987
Kind Code:
A
Abstract:
Dipiperazinyl ketones and related analogues are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).
Inventors:
Che, Lin Hong
Octelski, Joseph W..
Gao, Yang
Han, Vinson
Caldwell, Timothy M.
Shu, Yerien
Peterson, John M.
Gae, Pin
Oliger, Robert
Octelski, Joseph W..
Gao, Yang
Han, Vinson
Caldwell, Timothy M.
Shu, Yerien
Peterson, John M.
Gae, Pin
Oliger, Robert
Application Number:
JP2008525081A
Publication Date:
February 19, 2009
Filing Date:
July 28, 2006
Export Citation:
Assignee:
NEUROGEN CORPORATION
International Classes:
C07D207/14; A61K31/496; A61K31/497; A61K31/501; A61K31/502; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61K31/5513; A61P3/04; A61P3/10; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/28; A61P27/16; A61P37/08; C07D207/27; C07D211/14; C07D211/22; C07D211/26; C07D211/34; C07D211/52; C07D211/58; C07D211/70; C07D213/74; C07D213/82; C07D215/52; C07D217/06; C07D237/20; C07D237/28; C07D239/42; C07D241/04; C07D241/08; C07D241/20; C07D271/06; C07D277/82; C07D295/18; C07D295/20; C07D307/68; C07D317/66; C07D319/18; C07D333/38; C07D333/68; C07D401/04; C07D403/06; C07D405/04; C07D417/04; C07D487/10; C07D487/20; C07D491/107; C12N15/09
Domestic Patent References:
| JPH06271549A | 1994-09-27 | |||
| JPS5559107A | 1980-05-02 |
Foreign References:
| WO2004101546A1 | 2004-11-25 |
Attorney, Agent or Firm:
Katsuhiro Ito
Akiko Ono
Akiko Ono