Title:
ヒトCD38に特異的な完全ヒトHuCALGOLD由来の治療抗体の生成とプロファイリング
Document Type and Number:
Japanese Patent JP2009511033
Kind Code:
A
Abstract:
The present invention provides novel antibodies and methods for using recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These methods take advantage of newly discovered antibodies and surprising properties of such antibodies, such as the ability to bind CD38 of minipig origin and the ability to induce, by cross-linking, specific killing of cells that express CD38. There antibodies as well as the novel methods for using those antibodies can be used to treat, for example, hematological malignancies such as multiple myeloma.
Inventors:
Michael, Thessal
Application Number:
JP2008534940A
Publication Date:
March 19, 2009
Filing Date:
October 12, 2006
Export Citation:
Assignee:
Morphosis Age
International Classes:
C12N15/09; A61K39/395; A61P7/00; A61P17/00; A61P19/02; A61P29/00; A61P35/00; A61P35/02; C07K16/28; C12N1/21; C12N5/10; C12Q1/02; G01N33/53
Domestic Patent References:
| JPH10509876A | 1998-09-29 |
Foreign References:
| EP1174440A1 | 2002-01-23 |
Other References:
JPN6011046079; Ｓａｍｂｒｏｏｋ ＆ Ｒｕｓｓｅｌｌ，"Ｍｏｌｅｃｕｌａｒ Ｃｌｏｎｉｎｇ， Ａ Ｌａｂｏｒａｔｏｒｙ Ｍａｎｕａｌ"，３ｒｄ． Ｅｄ．，２００１，Ｖｏｌ．２，１０．４７
JPN6012022936; Ａｂｓｔｒａｃｔ： Ｇｅｎｅｒａｔｉｏｎ ａｎｄ ｐｒｏｆｉｌｉｎｇ ｏｆ ｆｕｌｌｙ ｈｕｍａｎ ｔｈｅｒａｐｅｕｔｉｃ ａｎｔｉｂｏｄｉｅｓ ａｇａｉｎｓｔ ＣＤ３８ ｆｏｒ ｔｈｅ ｔｒｅａｔｍ , 20050601, ＡＳＣＯ
JPN5008015922; ＥＬＬＩＳ ＪＯＮＡＴＨＡＮ Ｈ: ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＩＭＭＵＮＯＬＯＧＹ Ｖ１５５ Ｎ２, 1995, Ｐ９２５-９３７, ＴＨＥ ＷＩＬＬＩＡＭＳ ＡＮＤ ＷＩＬＫＩＮＳ ＣＯ
JPN6011046079; Ｓａｍｂｒｏｏｋ ＆ Ｒｕｓｓｅｌｌ，"Ｍｏｌｅｃｕｌａｒ Ｃｌｏｎｉｎｇ， Ａ Ｌａｂｏｒａｔｏｒｙ Ｍａｎｕａｌ"，３ｒｄ． Ｅｄ．，２００１，Ｖｏｌ．２，１０．４７
JPN6012022936; Ａｂｓｔｒａｃｔ： Ｇｅｎｅｒａｔｉｏｎ ａｎｄ ｐｒｏｆｉｌｉｎｇ ｏｆ ｆｕｌｌｙ ｈｕｍａｎ ｔｈｅｒａｐｅｕｔｉｃ ａｎｔｉｂｏｄｉｅｓ ａｇａｉｎｓｔ ＣＤ３８ ｆｏｒ ｔｈｅ ｔｒｅａｔｍ , 20050601, ＡＳＣＯ
JPN5008015922; ＥＬＬＩＳ ＪＯＮＡＴＨＡＮ Ｈ: ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＩＭＭＵＮＯＬＯＧＹ Ｖ１５５ Ｎ２, 1995, Ｐ９２５-９３７, ＴＨＥ ＷＩＬＬＩＡＭＳ ＡＮＤ ＷＩＬＫＩＮＳ ＣＯ
JPN6011046079; Ｓａｍｂｒｏｏｋ ＆ Ｒｕｓｓｅｌｌ，"Ｍｏｌｅｃｕｌａｒ Ｃｌｏｎｉｎｇ， Ａ Ｌａｂｏｒａｔｏｒｙ Ｍａｎｕａｌ"，３ｒｄ． Ｅｄ．，２００１，Ｖｏｌ．２，１０．４７
Attorney, Agent or Firm:
Mieko Kashihara