Title:
新規な方法
Document Type and Number:
Japanese Patent JP2009513578
Kind Code:
A
Abstract:
The present invention relates to processes for the preparation of 4-hydroxy-±'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (12a), the preparation of 4-hydroxy-±'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (salmeterol) (11), the preparation of protected N-[6-(4-phenylbutoxy)hexyl]amine intermediates (7), and the preparation of 6-substituted (4-phenylbutoxy)hexane intermediates (5), shown below, wherein X is a leaving group and Pg is a protecting group.
Inventors:
Vinayak Gee Gore
Avinash Sea Gei Quad
M Gadoker
B.K.Shkula
Avinash Sea Gei Quad
M Gadoker
B.K.Shkula
Application Number:
JP2008536115A
Publication Date:
April 02, 2009
Filing Date:
October 17, 2006
Export Citation:
Assignee:
Generics (Uke) Limited
International Classes:
C07C41/16; A61P11/08; A61P43/00; C07C43/174; C07C213/00; C07C213/02; C07C217/10; A61K31/137; C07B51/00; C07B61/00
Domestic Patent References:
| JPH1112219A | 1999-01-19 | |||
| JP2001247517A | 2001-09-11 | |||
| JP2002525349A | 2002-08-13 | |||
| JPH03133946A | 1991-06-07 | |||
| JPH0687800A | 1994-03-29 | |||
| JPH1112219A | 1999-01-19 | |||
| JP2001247517A | 2001-09-11 | |||
| JP2002525349A | 2002-08-13 | |||
| JPH03133946A | 1991-06-07 | |||
| JPH0687800A | 1994-03-29 |
Other References:
JPN6012024560; 'Ａ ＮＥＷ ＳＹＮＴＨＥＴＩＣ ＡＰＰＲＯＡＣＨ ＴＯ ＳＡＬＭＥＴＥＲＯＬ' ＳＹＮＴＨＥＴＩＣ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ ２９巻１２号, 19990518, ２１５５-２１６２頁
JPN6012024560; 'Ａ ＮＥＷ ＳＹＮＴＨＥＴＩＣ ＡＰＰＲＯＡＣＨ ＴＯ ＳＡＬＭＥＴＥＲＯＬ' ＳＹＮＴＨＥＴＩＣ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ ２９巻１２号, 19990518, ２１５５-２１６２頁
JPN6012024560; 'Ａ ＮＥＷ ＳＹＮＴＨＥＴＩＣ ＡＰＰＲＯＡＣＨ ＴＯ ＳＡＬＭＥＴＥＲＯＬ' ＳＹＮＴＨＥＴＩＣ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ ２９巻１２号, 19990518, ２１５５-２１６２頁
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro