Title:
グリコPEG化因子VIIおよび因子VIIA
Document Type and Number:
Japanese Patent JP2009515508
Kind Code:
A
Abstract:
The present invention provides conjugates between Factor VII or Factor VIIa peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
Inventors:
Defleece, sean
Zoff, David, A.
Toute, Susan
Willet, W., Scott
Buyer, Robert, Jay.
Caro, Matthew
Zoff, David, A.
Toute, Susan
Willet, W., Scott
Buyer, Robert, Jay.
Caro, Matthew
Application Number:
JP2008527212A
Publication Date:
April 16, 2009
Filing Date:
August 21, 2006
Export Citation:
Assignee:
Neos Technologies, Inc.
International Classes:
C12P21/02; C07K14/745
Foreign References:
| WO2005051327A2 | 2005-06-09 | |||
| WO2005055946A2 | 2005-06-23 | |||
| WO2005070138A2 | 2005-08-04 | |||
| WO2004099231A2 | 2004-11-18 | |||
| WO2005079363A2 | 2005-09-01 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Shinji Oga
Toshifumi Onuki
Shinji Oga
Toshifumi Onuki