Title:
血清応答因子及びミオカルディンは脳アミロイドアンギオパチーを制御する
Document Type and Number:
Japanese Patent JP2009515900
Kind Code:
A
Abstract:
Cerebral amyloid angiopathy is involved in Alzheimer dementia through reduction in arterial blood flow that may impair protein synthesis, which is required for learning and memory, and lower the threshold for ischemic injury. Elevated serum response factor (SRF) or myocardin (MYOCD) activity in subjects afflicted by or at risk for development of Alzheimer's disease (AD) promotes a "vascular smooth muscle cell" (VSMC) hypercontractile phenotype in brain arteries and enhance accumulation of Abeta in the vessel wall. This, in turn, can initiate a disease process in cerebral arteries which can cause brain arterial hypoperfusion and neurovascular uncoupling, that are commonly seen in AD. Thus, SRF and MYOCD represent novel targets for treating arterial dysfunction associated with cognitive decline in AD.
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Inventors:
Zrokovic, Belislav buoy
Miano, Joseph M
Miano, Joseph M
Application Number:
JP2008540274A
Publication Date:
April 16, 2009
Filing Date:
November 14, 2006
Export Citation:
Assignee:
Socratec LLC
University-City of Rochester-
University-City of Rochester-
International Classes:
A61K48/00; A61K31/7088; A61K31/7105; A61K35/12; A61K45/00; A61P9/00; A61P9/08; A61P25/28; A61P43/00; C12Q1/68; G01N33/68
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita