Title:
出血性ショックおよびその続発症を治療するための製剤
Document Type and Number:
Japanese Patent JP2009520696
Kind Code:
A
Abstract:
Use of a peptide comprising the N-terminal sequence or any allelic variant or its derivative, where the peptide has the biological property of matching the inducible vascular endothelial (VE) cadherin binding motif on the B beta -chain of human fibrin, for producing a pharmaceutical composition to treat shock, preferably hemorrhagic shock. Use of a peptide comprising the N-terminal sequence Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro-Ala-Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg or any allelic variant or its derivative, where the peptide has the biological property of matching the inducible vascular endothelial (VE) cadherin binding motif on the B beta -chain (i.e. Bbeta 1 5 - 4 2) of human fibrin, for producing a pharmaceutical composition to treat shock, preferably hemorrhagic shock. An independent claim is included for a procedure for the determination of the inflammation inhibiting effects of the peptide through measurement of the inhibition of the releasing of interleukin-6 (IL-6) of the endothelial cell after an exposition at the fibrin E fragment. ACTIVITY : Vasotropic; Antiinflammatory; Respiratory-Gen; Hepatotropic. MECHANISM OF ACTION : Interleukin-6 inhibitor.
Inventors:
Petchel bauer, peter
Henning, liner
Henning, liner
Application Number:
JP2008546020A
Publication Date:
May 28, 2009
Filing Date:
November 10, 2006
Export Citation:
Assignee:
Five Brex Medical Research and Development Game Behr
International Classes:
A61K38/00; A61K48/00; A61P1/16; A61P9/02; A61P11/00; A61P13/12; A61P29/00; C07K14/75
Domestic Patent References:
| JP2004527469A | 2004-09-09 |
Other References:
JPN6011021259; 日本外科学会雑誌 第１０４巻，第１２号, 2003, ｐ．８３５-８３９
Attorney, Agent or Firm:
Seiji Ohno
Koji Morita
Reiko Tanaka
Ken Kitano
Natsuki Ito
Koji Morita
Reiko Tanaka
Ken Kitano
Natsuki Ito