Title:
単鎖インスリンのアナログとその製薬的製剤
Document Type and Number:
Japanese Patent JP2009527526
Kind Code:
A
Abstract:
The present invention is related to fast acting single-chain insulin comprising a modified B-chain and the A-chain of human insulin or an analogue thereof connected by a connecting peptide wherein one or more of the amino acid residues in position B25, B26 or B27 in the human B-chain are Glu or Asp or are deleted and/or B28 is Glu, Asp, Lys or is deleted, and the amino acid residue in position B10 in the human insulin B-chain is Gln, Ala, Val, Thr or Ser. The invention is also related to pharmaceutical compositions being a mixture of the rapid acting single-chain insulin and the protracted acylated insulin.
Inventors:
Neighbor, Here
Kelsen, Thomas, Vogram
Kelsen, Thomas, Vogram
Application Number:
JP2008555770A
Publication Date:
July 30, 2009
Filing Date:
February 19, 2007
Export Citation:
Assignee:
Novo Nordeisk A/S
International Classes:
A61K38/28; A61P5/50; C07K14/62
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori