Title:
PSMAのペプチド模倣体阻害剤、それらを含む化合物、およびそれらの使用方法
Document Type and Number:
Japanese Patent JP2009532338
Kind Code:
A
Abstract:
Compounds of the formula, A—L—B, wherein A is glutamate or a glutamate analog; L is a phosphoramidate or a phosphoramidate analog; and B is serine or a serine analog are described which are potent inhibitors of prostate-specific membrane antigen (PMSA). Such compounds are useful in treatment of prostate cancer; and when chemically attached to a fluorescent dye, can efficiently and selectively label prostate cancer cells for fluorescent imaging.
Inventors:
Birkeman, Cliff
Application Number:
JP2009500598A
Publication Date:
September 10, 2009
Filing Date:
March 14, 2007
Export Citation:
Assignee:
Cancer Targeted Technology LLC
International Classes:
C07F9/24; A61K31/664; A61K49/00; A61K51/00; A61P13/08; A61P35/00; C07D311/90; C07D495/04; C07J1/00; C07J9/00; C12Q1/06; G01N21/78; G01N33/48; C07K5/027
Domestic Patent References:
| JP2005507857A | 2005-03-24 |
Other References:
JPN6012044151; ＢＯＯＫ ＯＦ ＡＢＳＴＲＡＣＴＳ， ２２９ＴＨ ＡＣＳ ＮＡＴＩＯＮＡＬ ＭＥＥＴＩＮＧ ２２９, 2005, ＭＥＤＩ４８０
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita