Title:
ラットおよび他種由来の多能性細胞
Document Type and Number:
Japanese Patent JP2009545302
Kind Code:
A
Abstract:
Pluripotent cells are derived and maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and an antagonist of an FGF receptor.
Inventors:
Inn, Qui-Ron
Smith, austin gerald
Smith, austin gerald
Application Number:
JP2009522328A
Publication Date:
December 24, 2009
Filing Date:
August 01, 2007
Export Citation:
Assignee:
The University Court of the University of Edinburgh
International Classes:
C12N5/02; C12N5/0735; C12N15/09
Foreign References:
| WO2007113705A1 | 2007-10-11 | |||
| WO2005085427A1 | 2005-09-15 | |||
| WO2005085427A1 | 2005-09-15 | |||
| WO2007113705A1 | 2007-10-11 |
Other References:
JPN6012041749; ＢＵＥＨＲ，Ｍ． ｅｔ ａｌ．: 'Ｃａｐｔｕｒｅ ｏｆ ａｕｔｈｅｎｔｉｃ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌｓ ｆｒｏｍ ｒａｔ ｂｌａｓｔｏｃｙｓｔｓ．' Ｃｅｌｌ Ｖｏｌ．１３５， Ｎｏ．７, 20081226, ｐｐ．１２８７-９８
JPN6012041750; ＬＩ，Ｐ． ｅｔ ａｌ．: 'Ｇｅｒｍｌｉｎｅ ｃｏｍｐｅｔｅｎｔ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌｓ ｄｅｒｉｖｅｄ ｆｒｏｍ ｒａｔ ｂｌａｓｔｏｃｙｓｔｓ．' Ｃｅｌｌ Ｖｏｌ．１３５， Ｎｏ．７, 20081226, ｐｐ．１２９９-３１０
JPN6012041752; ＹＩＮＧ，Ｑ．Ｌ． ｅｔ ａｌ．: 'Ｔｈｅ ｇｒｏｕｎｄ ｓｔａｔｅ ｏｆ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌ ｓｅｌｆ-ｒｅｎｅｗａｌ．' Ｎａｔｕｒｅ Ｖｏｌ．４５３， Ｎｏ．７１９４, 20080522, ｐｐ．５１９-２３
JPN6012041754; ＦＡＮＤＲＩＣＨ，Ｆ． ｅｔ ａｌ．: 'Ｐｒｅｉｍｐｌａｎｔａｔｉｏｎ-ｓｔａｇｅ ｓｔｅｍ ｃｅｌｌｓ ｉｎｄｕｃｅ ｌｏｎｇ-ｔｅｒｍ ａｌｌｏｇｅｎｅｉｃ ｇｒａｆｔ ａｃｃｅｐｔａｎｃｅ ｗｉｔｈｏｕｔ ｓｕｐｐｌｅｍｅｎｔａｒｙ' Ｎａｔ． Ｍｅｄ． Ｖｏｌ．８， Ｎｏ．２, 200202, ｐｐ．１７１-８
JPN6012041755; ＶＡＳＳＩＬＬＩＥＶＡ，Ｓ． ｅｔ ａｌ．: 'Ｅｓｔａｂｌｉｓｈｍｅｎｔ ｏｆ ＳＳＥＡ-１- ａｎｄ Ｏｃｔ-４-ｅｘｐｒｅｓｓｉｎｇ ｒａｔ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ-ｌｉｋｅ ｃｅｌｌ ｌｉｎｅｓ ａｎｄ ｅｆｆｅｃｔｓ ｏｆ ｃｙｔｏ' Ｅｘｐ． Ｃｅｌｌ Ｒｅｓ． Ｖｏｌ．２５８， Ｎｏ．２, 20000801, ｐｐ．３６１-７３
JPN6012041749; ＢＵＥＨＲ，Ｍ． ｅｔ ａｌ．: 'Ｃａｐｔｕｒｅ ｏｆ ａｕｔｈｅｎｔｉｃ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌｓ ｆｒｏｍ ｒａｔ ｂｌａｓｔｏｃｙｓｔｓ．' Ｃｅｌｌ Ｖｏｌ．１３５， Ｎｏ．７, 20081226, ｐｐ．１２８７-９８
JPN6012041750; ＬＩ，Ｐ． ｅｔ ａｌ．: 'Ｇｅｒｍｌｉｎｅ ｃｏｍｐｅｔｅｎｔ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌｓ ｄｅｒｉｖｅｄ ｆｒｏｍ ｒａｔ ｂｌａｓｔｏｃｙｓｔｓ．' Ｃｅｌｌ Ｖｏｌ．１３５， Ｎｏ．７, 20081226, ｐｐ．１２９９-３１０
JPN6012041752; ＹＩＮＧ，Ｑ．Ｌ． ｅｔ ａｌ．: 'Ｔｈｅ ｇｒｏｕｎｄ ｓｔａｔｅ ｏｆ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌ ｓｅｌｆ-ｒｅｎｅｗａｌ．' Ｎａｔｕｒｅ Ｖｏｌ．４５３， Ｎｏ．７１９４, 20080522, ｐｐ．５１９-２３
JPN6012041754; ＦＡＮＤＲＩＣＨ，Ｆ． ｅｔ ａｌ．: 'Ｐｒｅｉｍｐｌａｎｔａｔｉｏｎ-ｓｔａｇｅ ｓｔｅｍ ｃｅｌｌｓ ｉｎｄｕｃｅ ｌｏｎｇ-ｔｅｒｍ ａｌｌｏｇｅｎｅｉｃ ｇｒａｆｔ ａｃｃｅｐｔａｎｃｅ ｗｉｔｈｏｕｔ ｓｕｐｐｌｅｍｅｎｔａｒｙ' Ｎａｔ． Ｍｅｄ． Ｖｏｌ．８， Ｎｏ．２, 200202, ｐｐ．１７１-８
JPN6012041755; ＶＡＳＳＩＬＬＩＥＶＡ，Ｓ． ｅｔ ａｌ．: 'Ｅｓｔａｂｌｉｓｈｍｅｎｔ ｏｆ ＳＳＥＡ-１- ａｎｄ Ｏｃｔ-４-ｅｘｐｒｅｓｓｉｎｇ ｒａｔ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ-ｌｉｋｅ ｃｅｌｌ ｌｉｎｅｓ ａｎｄ ｅｆｆｅｃｔｓ ｏｆ ｃｙｔｏ' Ｅｘｐ． Ｃｅｌｌ Ｒｅｓ． Ｖｏｌ．２５８， Ｎｏ．２, 20000801, ｐｐ．３６１-７３
JPN6012041750; ＬＩ，Ｐ． ｅｔ ａｌ．: 'Ｇｅｒｍｌｉｎｅ ｃｏｍｐｅｔｅｎｔ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌｓ ｄｅｒｉｖｅｄ ｆｒｏｍ ｒａｔ ｂｌａｓｔｏｃｙｓｔｓ．' Ｃｅｌｌ Ｖｏｌ．１３５， Ｎｏ．７, 20081226, ｐｐ．１２９９-３１０
JPN6012041752; ＹＩＮＧ，Ｑ．Ｌ． ｅｔ ａｌ．: 'Ｔｈｅ ｇｒｏｕｎｄ ｓｔａｔｅ ｏｆ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌ ｓｅｌｆ-ｒｅｎｅｗａｌ．' Ｎａｔｕｒｅ Ｖｏｌ．４５３， Ｎｏ．７１９４, 20080522, ｐｐ．５１９-２３
JPN6012041754; ＦＡＮＤＲＩＣＨ，Ｆ． ｅｔ ａｌ．: 'Ｐｒｅｉｍｐｌａｎｔａｔｉｏｎ-ｓｔａｇｅ ｓｔｅｍ ｃｅｌｌｓ ｉｎｄｕｃｅ ｌｏｎｇ-ｔｅｒｍ ａｌｌｏｇｅｎｅｉｃ ｇｒａｆｔ ａｃｃｅｐｔａｎｃｅ ｗｉｔｈｏｕｔ ｓｕｐｐｌｅｍｅｎｔａｒｙ' Ｎａｔ． Ｍｅｄ． Ｖｏｌ．８， Ｎｏ．２, 200202, ｐｐ．１７１-８
JPN6012041755; ＶＡＳＳＩＬＬＩＥＶＡ，Ｓ． ｅｔ ａｌ．: 'Ｅｓｔａｂｌｉｓｈｍｅｎｔ ｏｆ ＳＳＥＡ-１- ａｎｄ Ｏｃｔ-４-ｅｘｐｒｅｓｓｉｎｇ ｒａｔ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ-ｌｉｋｅ ｃｅｌｌ ｌｉｎｅｓ ａｎｄ ｅｆｆｅｃｔｓ ｏｆ ｃｙｔｏ' Ｅｘｐ． Ｃｅｌｌ Ｒｅｓ． Ｖｏｌ．２５８， Ｎｏ．２, 20000801, ｐｐ．３６１-７３
JPN6012041749; ＢＵＥＨＲ，Ｍ． ｅｔ ａｌ．: 'Ｃａｐｔｕｒｅ ｏｆ ａｕｔｈｅｎｔｉｃ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌｓ ｆｒｏｍ ｒａｔ ｂｌａｓｔｏｃｙｓｔｓ．' Ｃｅｌｌ Ｖｏｌ．１３５， Ｎｏ．７, 20081226, ｐｐ．１２８７-９８
JPN6012041750; ＬＩ，Ｐ． ｅｔ ａｌ．: 'Ｇｅｒｍｌｉｎｅ ｃｏｍｐｅｔｅｎｔ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌｓ ｄｅｒｉｖｅｄ ｆｒｏｍ ｒａｔ ｂｌａｓｔｏｃｙｓｔｓ．' Ｃｅｌｌ Ｖｏｌ．１３５， Ｎｏ．７, 20081226, ｐｐ．１２９９-３１０
JPN6012041752; ＹＩＮＧ，Ｑ．Ｌ． ｅｔ ａｌ．: 'Ｔｈｅ ｇｒｏｕｎｄ ｓｔａｔｅ ｏｆ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ ｃｅｌｌ ｓｅｌｆ-ｒｅｎｅｗａｌ．' Ｎａｔｕｒｅ Ｖｏｌ．４５３， Ｎｏ．７１９４, 20080522, ｐｐ．５１９-２３
JPN6012041754; ＦＡＮＤＲＩＣＨ，Ｆ． ｅｔ ａｌ．: 'Ｐｒｅｉｍｐｌａｎｔａｔｉｏｎ-ｓｔａｇｅ ｓｔｅｍ ｃｅｌｌｓ ｉｎｄｕｃｅ ｌｏｎｇ-ｔｅｒｍ ａｌｌｏｇｅｎｅｉｃ ｇｒａｆｔ ａｃｃｅｐｔａｎｃｅ ｗｉｔｈｏｕｔ ｓｕｐｐｌｅｍｅｎｔａｒｙ' Ｎａｔ． Ｍｅｄ． Ｖｏｌ．８， Ｎｏ．２, 200202, ｐｐ．１７１-８
JPN6012041755; ＶＡＳＳＩＬＬＩＥＶＡ，Ｓ． ｅｔ ａｌ．: 'Ｅｓｔａｂｌｉｓｈｍｅｎｔ ｏｆ ＳＳＥＡ-１- ａｎｄ Ｏｃｔ-４-ｅｘｐｒｅｓｓｉｎｇ ｒａｔ ｅｍｂｒｙｏｎｉｃ ｓｔｅｍ-ｌｉｋｅ ｃｅｌｌ ｌｉｎｅｓ ａｎｄ ｅｆｆｅｃｔｓ ｏｆ ｃｙｔｏ' Ｅｘｐ． Ｃｅｌｌ Ｒｅｓ． Ｖｏｌ．２５８， Ｎｏ．２, 20000801, ｐｐ．３６１-７３
Attorney, Agent or Firm:
Hiromichi Nanjo