Title:
置換ヘテロアリールピリドピリミドン誘導体
Document Type and Number:
Japanese Patent JP2010513463
Kind Code:
A
Abstract:
A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof :
wherein:
Y represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C 1-2 alkyl group and a hydrogen atom;
Z represents a bond, an oxygen atom, a nitrogen atom, a sulphur atom, a methylene group optionally substituted by one or two groups chosen from a C 1-6 alkyl group, a hydroxyl group, a C 1-6 alkoxy group, a C 1-2 perhalogenated alkyl group or an amino group;
R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring;
R2 represents a 4-15 membered heterocyclic group , R3 represents a hydrogen atom, a C 1-6 alkyl group or a halogen atom; R4 and R5 represent, each independently, a hydrogen atom, a C 1-6 alkyl group, optionally substituted by 1 to 4 substituents selected from a halogen atom, a phenyl group, a hydroxyl group or a C 1-6 alkoxy group; R6 represents a hydrogen atom, a C 1-6 alkyl group ; a cycloalkyl group, or a halogen atom; R7 represents a hydrogen atom or a C 1-6 alkyl group;
n represents 0 to 3; m represents 0 to 1; o represents 0 to 2; in the form of a free base or of an addition salt with an acid. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3², such as Alzheimer disease.
Inventors:
Huayor, Aether
Galle, Chierry
Rotido, alistair
Mura, Saturday
Veronique, Corrine
Yesilles
Galle, Chierry
Rotido, alistair
Mura, Saturday
Veronique, Corrine
Yesilles
Application Number:
JP2009542272A
Publication Date:
April 30, 2010
Filing Date:
December 20, 2007
Export Citation:
Assignee:
Sanofui-Aventice
Mitsubishi Tanabe Pharma Corporation
Mitsubishi Tanabe Pharma Corporation
International Classes:
C07D471/04; A61K31/519; A61P3/04; A61P3/10; A61P9/00; A61P17/00; A61P17/02; A61P17/14; A61P19/08; A61P25/02; A61P25/16; A61P25/18; A61P25/28; A61P27/00; A61P27/06; A61P33/06; A61P35/00; A61P35/02; A61P43/00; C07D519/00
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura