Title:
疼痛治療のためのTRPV1バニロイド受容体アンタゴニストとしてのN-(5,6,7,8-テトラヒドロナフタレン-1-イル)尿素誘導体および関連化合物
Document Type and Number:
Japanese Patent JP2010513557
Kind Code:
A
Abstract:
The present application is directed to compounds that are TRPV1 antagonists and have formula(I): wherein variables Ar 1 , L 1 , R 1 , R 2 , R 3 , R 4 , R 5 , Y 1 , Y 2 , and Y 3 , are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.
Inventors:
Gomutsuyan, Arthur Earl
Robert Smith
Danen, Jerome F
Bybert eror kay
Lee, Chi-Han
Ratsyou, Stephen Pee
Robert Smith
Danen, Jerome F
Bybert eror kay
Lee, Chi-Han
Ratsyou, Stephen Pee
Application Number:
JP2009543075A
Publication Date:
April 30, 2010
Filing Date:
December 12, 2007
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
C07C275/34; A61K31/17; A61K31/352; A61K31/353; A61K31/47; A61K31/4706; A61P13/10; A61P25/02; A61P25/06; A61P29/00; A61P43/00; C07D215/12; C07D215/38; C07D215/46; C07D311/04; C07D311/68; C07D311/92
Domestic Patent References:
| JP2005516918A | 2005-06-09 | |||
| JP2002536445A | 2002-10-29 | |||
| JPH04178363A | 1992-06-25 | |||
| JP2006509018A | 2006-03-16 | |||
| JP2006509017A | 2006-03-16 | |||
| JP2005524717A | 2005-08-18 |
Foreign References:
| WO2003051275A2 | 2003-06-26 | |||
| EP0591830A1 | 1994-04-13 | |||
| WO2006065484A2 | 2006-06-22 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura