Title:
4-フェニルアミノキナゾリン誘導体の塩形態
Document Type and Number:
Japanese Patent JP2010518173
Kind Code:
A
Abstract:
The present invention relates to salt forms of N-{4-[3-chloro-4-(3-fluoro-benzyloxy)phenylamino]-quinazolin-6-yl}-acrylamide, methods for preparation thereof, pharmaceutical compositions comprising the same and their use thereof. The salt forms of the present invention, which possess excellent tumor inhibitory activity, good bioavailability and low toxicity in an animal body, are suitable for the use of preparation of anti-tumor medicaments.
Inventors:
Guo Jian
Ginger courage
Ginger courage
Application Number:
JP2009549760A
Publication Date:
May 27, 2010
Filing Date:
February 04, 2008
Export Citation:
Assignee:
Shanghai Agricultural Technology Co., Ltd.
International Classes:
C07D239/94; A61K31/517; A61K45/00; A61P35/00
Domestic Patent References:
| JP2002500225A | 2002-01-08 | |||
| JPH10505600A | 1998-06-02 | |||
| JP2002500225A | 2002-01-08 | |||
| JPH10505600A | 1998-06-02 | |||
| JP2009525956A | 2009-07-16 |
Foreign References:
| WO2006071017A1 | 2006-07-06 | |||
| WO1999035132A1 | 1999-07-15 | |||
| WO1999035132A1 | 1999-07-15 | |||
| WO2006071017A1 | 2006-07-06 |
Other References:
JPN6011051899; ＴＳＯＵ，Ｈ． ｅｔ ａｌ: '６-Ｓｕｂｓｔｉｔｕｔｅｄ-４-（３-ｂｒｏｍｏｐｈｅｎｙｌａｍｉｎｏ）ｑｕｉｎａｚｏｌｉｎｅｓ ａｓ Ｐｕｔａｔｉｖｅ Ｉｒｒｅｖｅｒｓｉｂｌｅ Ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ Ｅｐｉｄｅｒｍａ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４４， Ｎｏ．１７, 2001, ｐ．２７１９-２７３４
JPN6011051899; ＴＳＯＵ，Ｈ． ｅｔ ａｌ: '６-Ｓｕｂｓｔｉｔｕｔｅｄ-４-（３-ｂｒｏｍｏｐｈｅｎｙｌａｍｉｎｏ）ｑｕｉｎａｚｏｌｉｎｅｓ ａｓ Ｐｕｔａｔｉｖｅ Ｉｒｒｅｖｅｒｓｉｂｌｅ Ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ Ｅｐｉｄｅｒｍａ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４４， Ｎｏ．１７, 2001, ｐ．２７１９-２７３４
JPN6011051899; ＴＳＯＵ，Ｈ． ｅｔ ａｌ: '６-Ｓｕｂｓｔｉｔｕｔｅｄ-４-（３-ｂｒｏｍｏｐｈｅｎｙｌａｍｉｎｏ）ｑｕｉｎａｚｏｌｉｎｅｓ ａｓ Ｐｕｔａｔｉｖｅ Ｉｒｒｅｖｅｒｓｉｂｌｅ Ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ Ｅｐｉｄｅｒｍａ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４４， Ｎｏ．１７, 2001, ｐ．２７１９-２７３４
Attorney, Agent or Firm:
Kuro Fukami
Toshio Morita
Yoshihei Nakamura
Yutaka Horii
Masayuki Sakai
Nobuo Arakawa
Masato Sasaki
Toshio Morita
Yoshihei Nakamura
Yutaka Horii
Masayuki Sakai
Nobuo Arakawa
Masato Sasaki