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Title:
β-ケトニトリルの製造方法
Document Type and Number:
Japanese Patent JP2010520180
Kind Code:
A
Abstract:
The present invention relates to a process for preparing beta-ketonitriles of the general formula I in which R1 is, inter alia, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkinyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl; R2 is, inter alia, hydrogen, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkinyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl, which comprises reacting a nitrile of the formula II in which R1 has one of the meanings given above with a carboxylic ester of the formula III in which R2 has one of the meanings given above and R3 is C1-C12-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl, where the reaction is carried out in the presence of a potassium alkoxide and at least 80% of the nitrile of the formula II are added to the reaction under reaction conditions.

Inventors:
Fogelbacher, Uve Joseph
Otto, Peter
Rack, michael
Application Number:
JP2009551226A
Publication Date:
June 10, 2010
Filing Date:
February 29, 2008
Export Citation:
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Assignee:
BASF SE
International Classes:
C07C253/30; C07C255/17; C07D487/04; C07B61/00
Domestic Patent References:
JP2003113153A2003-04-18
JP2006312644A2006-11-16
JP2002293766A2002-10-09
JPS63264448A1988-11-01
JP2003012630A2003-01-15
JPH11279178A1999-10-12
JPS60104089A1985-06-08
JPS58167554A1983-10-03
JP2003113153A2003-04-18
JP2006312644A2006-11-16
JP2002293766A2002-10-09
JPS63264448A1988-11-01
JP2003012630A2003-01-15
JPH11279178A1999-10-12
JPS60104089A1985-06-08
Foreign References:
US20040171863A12004-09-02
WO2006087325A12006-08-24
WO2006092412A12006-09-08
US20040171863A12004-09-02
Other References:
JPN5010005131; YAOHUI, J. et al.: ORGANIC LETTERS V8 N6, 20060223, P1161-1163
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai