Title:
β-ケトニトリルの製造方法
Document Type and Number:
Japanese Patent JP2010520180
Kind Code:
A
Abstract:
The present invention relates to a process for preparing beta-ketonitriles of the general formula I in which R1 is, inter alia, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkinyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl; R2 is, inter alia, hydrogen, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkinyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl, which comprises reacting a nitrile of the formula II in which R1 has one of the meanings given above with a carboxylic ester of the formula III in which R2 has one of the meanings given above and R3 is C1-C12-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, phenoxy-C1-C4-alkyl or benzyloxy-C1-C4-alkyl, where the reaction is carried out in the presence of a potassium alkoxide and at least 80% of the nitrile of the formula II are added to the reaction under reaction conditions.
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Inventors:
Fogelbacher, Uve Joseph
Otto, Peter
Rack, michael
Otto, Peter
Rack, michael
Application Number:
JP2009551226A
Publication Date:
June 10, 2010
Filing Date:
February 29, 2008
Export Citation:
Assignee:
BASF SE
International Classes:
C07C253/30; C07C255/17; C07D487/04; C07B61/00
Domestic Patent References:
| JP2003113153A | 2003-04-18 | |||
| JP2006312644A | 2006-11-16 | |||
| JP2002293766A | 2002-10-09 | |||
| JPS63264448A | 1988-11-01 | |||
| JP2003012630A | 2003-01-15 | |||
| JPH11279178A | 1999-10-12 | |||
| JPS60104089A | 1985-06-08 | |||
| JPS58167554A | 1983-10-03 | |||
| JP2003113153A | 2003-04-18 | |||
| JP2006312644A | 2006-11-16 | |||
| JP2002293766A | 2002-10-09 | |||
| JPS63264448A | 1988-11-01 | |||
| JP2003012630A | 2003-01-15 | |||
| JPH11279178A | 1999-10-12 | |||
| JPS60104089A | 1985-06-08 |
Foreign References:
| US20040171863A1 | 2004-09-02 | |||
| WO2006087325A1 | 2006-08-24 | |||
| WO2006092412A1 | 2006-09-08 | |||
| US20040171863A1 | 2004-09-02 |
Other References:
JPN5010005131; ＹＡＯＨＵＩ， Ｊ． ｅｔ ａｌ．: ＯＲＧＡＮＩＣ ＬＥＴＴＥＲＳ Ｖ８ Ｎ６, 20060223, Ｐ１１６１-１１６３
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Ishii Teiji
Satoshi Fujita
Eiichi Arai