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Title:
活性ポリオキサゾリンおよびそれを含む組成物
Document Type and Number:
Japanese Patent JP2010529212
Kind Code:
A
Abstract:
The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed terminally activated monofunctional POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives.

Inventors:
Harris, J. Milton
Bentley, Michael David
Yun, Gunsan
Juan, Zihao
Veronese, Franciesco Maria
Application Number:
JP2009551999A
Publication Date:
August 26, 2010
Filing Date:
February 28, 2008
Export Citation:
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Assignee:
Serina Therapy Co., Ltd.
International Classes:
C08G73/02; A61K47/34; A61K47/48; C07D207/444; C07D207/46; C07D401/12
Domestic Patent References:
JPH02182724A1990-07-17
JPH02182724A1990-07-17
Foreign References:
WO2006052649A22006-05-18
US20060051315A12006-03-09
US5635571A1997-06-03
WO2007026932A12007-03-08
WO2006052649A22006-05-18
US20060051315A12006-03-09
US5635571A1997-06-03
Other References:
JPN6013063971; Bioconjugate Chem. vol.17, no.3, 2006, p.781-786
JPN6013063972; Macromolecules vol.34, no.26, 2001, p.8858-8865
JPN6013063978; Macromol. Chem. Phys. vol.197, 1996, p.2811-2826
JPN5010002682; VELANDER: BIOTECHNOLOGY AND BIOENGINEERING V39 N10, 19920425, P1024-1030
JPN6013063975; Macromelecules vol.23, no.13, 1990, p.3201-3205
JPN6013063980; Journal of Pharmaceutical Sciences vol.85, no.2, 1996, p.133-137
JPN6013063971; Bioconjugate Chem. vol.17, no.3, 2006, p.781-786
JPN6013063972; Macromolecules vol.34, no.26, 2001, p.8858-8865
JPN6013063978; Macromol. Chem. Phys. vol.197, 1996, p.2811-2826
JPN5010002682; VELANDER: BIOTECHNOLOGY AND BIOENGINEERING V39 N10, 19920425, P1024-1030
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura