Title:
活性ポリオキサゾリンおよびそれを含む組成物
Document Type and Number:
Japanese Patent JP2010529212
Kind Code:
A
Abstract:
The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed terminally activated monofunctional POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives.
Inventors:
Harris, J. Milton
Bentley, Michael David
Yun, Gunsan
Juan, Zihao
Veronese, Franciesco Maria
Bentley, Michael David
Yun, Gunsan
Juan, Zihao
Veronese, Franciesco Maria
Application Number:
JP2009551999A
Publication Date:
August 26, 2010
Filing Date:
February 28, 2008
Export Citation:
Assignee:
Serina Therapy Co., Ltd.
International Classes:
C08G73/02; A61K47/34; A61K47/48; C07D207/444; C07D207/46; C07D401/12
Domestic Patent References:
| JPH02182724A | 1990-07-17 | |||
| JPH02182724A | 1990-07-17 |
Foreign References:
| WO2006052649A2 | 2006-05-18 | |||
| US20060051315A1 | 2006-03-09 | |||
| US5635571A | 1997-06-03 | |||
| WO2007026932A1 | 2007-03-08 | |||
| WO2006052649A2 | 2006-05-18 | |||
| US20060051315A1 | 2006-03-09 | |||
| US5635571A | 1997-06-03 |
Other References:
JPN6013063971; Ｂｉｏｃｏｎｊｕｇａｔｅ Ｃｈｅｍ． ｖｏｌ．１７， ｎｏ．３, 2006, ｐ．７８１-７８６
JPN6013063972; Ｍａｃｒｏｍｏｌｅｃｕｌｅｓ ｖｏｌ．３４， ｎｏ．２６, 2001, ｐ．８８５８-８８６５
JPN6013063978; Ｍａｃｒｏｍｏｌ． Ｃｈｅｍ． Ｐｈｙｓ． ｖｏｌ．１９７, 1996, ｐ．２８１１-２８２６
JPN5010002682; ＶＥＬＡＮＤＥＲ: ＢＩＯＴＥＣＨＮＯＬＯＧＹ ＡＮＤ ＢＩＯＥＮＧＩＮＥＥＲＩＮＧ Ｖ３９ Ｎ１０, 19920425, Ｐ１０２４-１０３０
JPN6013063975; Ｍａｃｒｏｍｅｌｅｃｕｌｅｓ ｖｏｌ．２３， ｎｏ．１３, 1990, ｐ．３２０１-３２０５
JPN6013063980; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ ｖｏｌ．８５， ｎｏ．２, 1996, ｐ．１３３-１３７
JPN6013063971; Ｂｉｏｃｏｎｊｕｇａｔｅ Ｃｈｅｍ． ｖｏｌ．１７， ｎｏ．３, 2006, ｐ．７８１-７８６
JPN6013063972; Ｍａｃｒｏｍｏｌｅｃｕｌｅｓ ｖｏｌ．３４， ｎｏ．２６, 2001, ｐ．８８５８-８８６５
JPN6013063978; Ｍａｃｒｏｍｏｌ． Ｃｈｅｍ． Ｐｈｙｓ． ｖｏｌ．１９７, 1996, ｐ．２８１１-２８２６
JPN5010002682; ＶＥＬＡＮＤＥＲ: ＢＩＯＴＥＣＨＮＯＬＯＧＹ ＡＮＤ ＢＩＯＥＮＧＩＮＥＥＲＩＮＧ Ｖ３９ Ｎ１０, 19920425, Ｐ１０２４-１０３０
JPN6013063972; Ｍａｃｒｏｍｏｌｅｃｕｌｅｓ ｖｏｌ．３４， ｎｏ．２６, 2001, ｐ．８８５８-８８６５
JPN6013063978; Ｍａｃｒｏｍｏｌ． Ｃｈｅｍ． Ｐｈｙｓ． ｖｏｌ．１９７, 1996, ｐ．２８１１-２８２６
JPN5010002682; ＶＥＬＡＮＤＥＲ: ＢＩＯＴＥＣＨＮＯＬＯＧＹ ＡＮＤ ＢＩＯＥＮＧＩＮＥＥＲＩＮＧ Ｖ３９ Ｎ１０, 19920425, Ｐ１０２４-１０３０
JPN6013063975; Ｍａｃｒｏｍｅｌｅｃｕｌｅｓ ｖｏｌ．２３， ｎｏ．１３, 1990, ｐ．３２０１-３２０５
JPN6013063980; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ ｖｏｌ．８５， ｎｏ．２, 1996, ｐ．１３３-１３７
JPN6013063971; Ｂｉｏｃｏｎｊｕｇａｔｅ Ｃｈｅｍ． ｖｏｌ．１７， ｎｏ．３, 2006, ｐ．７８１-７８６
JPN6013063972; Ｍａｃｒｏｍｏｌｅｃｕｌｅｓ ｖｏｌ．３４， ｎｏ．２６, 2001, ｐ．８８５８-８８６５
JPN6013063978; Ｍａｃｒｏｍｏｌ． Ｃｈｅｍ． Ｐｈｙｓ． ｖｏｌ．１９７, 1996, ｐ．２８１１-２８２６
JPN5010002682; ＶＥＬＡＮＤＥＲ: ＢＩＯＴＥＣＨＮＯＬＯＧＹ ＡＮＤ ＢＩＯＥＮＧＩＮＥＥＲＩＮＧ Ｖ３９ Ｎ１０, 19920425, Ｐ１０２４-１０３０
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura