Title:
カチオン性基及び疎水性基により官能基化したポリグルタミン酸及びその応用、特にはその治療への応用
Document Type and Number:
Japanese Patent JP2010529214
Kind Code:
A
Abstract:
The present invention relates to novel biodegradable materials based on modified polyamino acids that are useful in particular in the vectorization of active principle(s) (APs). The invention is also directed to novel pharmaceutical, cosmetic, health-food or plant-protection compositions based on these polyamino acids. The aim of the invention is to provide a novel polymeric starting material which can be used for AP vectorization and which satisfy all the requirements: biocompatibility, biodegradability, ability to easily associate with or dissolve numerous active principles and to release these active principles in vivo. This goal is achieved by the present invention, which relates to novel polyglutamates modified by cationic groups, which, if they can be deprotonated, exhibit a pKa equal to or greater than 7, and by hydrophobic groups comprising from 8 to 30 carbon atoms. These polyglutamates modified by cationic groups are easily and economically converted into particles for the vectorization of active principles, these particles being themselves capable of forming stable aqueous colloidal suspensions. These modified polyglutamates exhibit the advantage of being less viscous than other analogous polymers while retaining an ability to associate proteins, such as insulin. Some are soluble in water at acidic pH and become insoluble at physiological pH (7.4) and should thus, during subcutaneous injection, precipitate on the site of injection.
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Inventors:
Yu-Ping Chan
Olivier Blaine
Cecile Bonnet Gonet
Olivier Blaine
Cecile Bonnet Gonet
Application Number:
JP2010504757A
Publication Date:
August 26, 2010
Filing Date:
May 05, 2008
Export Citation:
Assignee:
Flamel Technologies
International Classes:
C08G69/10; A61K8/88; A61K9/107; A61K9/14; A61K47/34; C07K14/00; C07C229/24
Domestic Patent References:
| JP2005531652A | 2005-10-20 | |||
| JP2006503124A | 2006-01-26 | |||
| JP2002069177A | 2002-03-08 | |||
| JP2009007547A | 2009-01-15 | |||
| JP2002194078A | 2002-07-10 | |||
| JP2006077037A | 2006-03-23 | |||
| JP2002194078A | 2002-07-10 | |||
| JP2006077037A | 2006-03-23 |
Attorney, Agent or Firm:
Kenji Sugimura
Kazuyuki Tomita
Yoichi Iino
Kazuyuki Tomita
Yoichi Iino