Title:
多重分化能性/多能性細胞及び方法
Document Type and Number:
Japanese Patent JP2010529851
Kind Code:
A
Abstract:
To establish human pluripotent stem cells having properties close to human ES cells comprising the genome of the patient per se that can circumvent immunological rejection of transplanted cells from cells derived from a postnatal human tissue. It was found that human pluripotent stem cells can be induced by introducing three genes of Oct3/4, Sox2 and Klf 4, or three genes of Oct3/4, Sox2 and Klf 4 plus the c-Myc gene or a histone deacetylase (HDAC) inhibitor to undifferentiated stem cells present in various human postnatal tissues in which each gene of Tert, 1 Nanog, Oct3/4 and Sox2 has not undergone epigenetic inactivation.
Inventors:
Kazuhiro Sakurada
Masaki Hideki
Tetsuya Ishikawa
Shunichi Takahashi
Masaki Hideki
Tetsuya Ishikawa
Shunichi Takahashi
Application Number:
JP2010511743A
Publication Date:
September 02, 2010
Filing Date:
June 13, 2008
Export Citation:
Assignee:
IPIA Ryan, Incorporated
International Classes:
C12N5/0735; A61L27/00; C12N5/07; C12N5/071; C12N5/074; C12N5/0775; C12N5/0789; C12N5/0797; C12N15/09; C12N15/85; C12Q1/68
Domestic Patent References:
| JP2007117081A | 2007-05-17 |
Foreign References:
| WO2007069666A1 | 2007-06-21 |
Other References:
CELL. 2006 AUG 25;126(4):663-76. EPUB 2006 AUG 10., JPN6013038430, ISSN: 0002599084
NATURE. 2007 JUL 19;448(7151):318-24. EPUB 2007 JUN 6., JPN6013038432, ISSN: 0002599085
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CELL STEM CELL. 2007 JUN 7;1(1):55-70., JPN6013038436, ISSN: 0002599087
NAT BIOTECHNOL. 2007 JUN;25(6):681-6. EPUB 2007 MAY 27., JPN6013038440, ISSN: 0002599088
STEM CELL RES. VOLUME 1, ISSUE 2, JUNE 2008, PAGES 105-115, EPUB 2008 JAN 31., JPN6013038445, ISSN: 0002789471
BIOCHEM BIOPHYS RES COMMUN. 2006 FEB 3;340(1):183-9. EPUB 2005 DEC 9., JPN6013038441, ISSN: 0002789469
BIOL REPROD. 2006 JUN;74(6):1083-9. EPUB 2006 FEB 15., JPN6013038443, ISSN: 0002789470
NATURE. 2007 JUL 19;448(7151):318-24. EPUB 2007 JUN 6., JPN6013038432, ISSN: 0002599085
NATURE. 2007 JUL 19;448(7151):313-7. EPUB 2007 JUN 6., JPN6013038434, ISSN: 0002599086
CELL STEM CELL. 2007 JUN 7;1(1):55-70., JPN6013038436, ISSN: 0002599087
NAT BIOTECHNOL. 2007 JUN;25(6):681-6. EPUB 2007 MAY 27., JPN6013038440, ISSN: 0002599088
STEM CELL RES. VOLUME 1, ISSUE 2, JUNE 2008, PAGES 105-115, EPUB 2008 JAN 31., JPN6013038445, ISSN: 0002789471
BIOCHEM BIOPHYS RES COMMUN. 2006 FEB 3;340(1):183-9. EPUB 2005 DEC 9., JPN6013038441, ISSN: 0002789469
BIOL REPROD. 2006 JUN;74(6):1083-9. EPUB 2006 FEB 15., JPN6013038443, ISSN: 0002789470
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima