Title:
新規化合物、小胞系に影響を及ぼす化合物、医薬組成物及びその使用
Document Type and Number:
Japanese Patent JP2010530410
Kind Code:
A
Abstract:
The present invention relates to compounds that are suitable for treatment of disease states and influence cellular vesicular systems, especially the formation and/or function of lipid droplets, said compound having the general formula I (I) wherein X are each independently hydrogen, halogen, —C1-20-alkyl, —C2-20-alkenyl, —C2-20-alkinyl, —C5-6-cykloalkyl, aryl, aralkyl, adamantyl, heterocyclic, hydroxyl, hydroxyalkyl, Or —N—(R1, R2) group; n is 0, 1, 2, 3, or 4; R1 and R2 may each be independently hydrogen, straight or branching alkyl, cyclo-alkyl, aryl, aralkyl, heterocyclic group, wherein each is un-substituted or halogen substituted; or R1 and R2 together with the nitrogen in between them form a 5 or 6 member ring; A is a single bond, —O—, —S—, —CH2-, or —NH—; Y is O or S; Z is O or S; R′ and R″ are each independently methyl, ethyl, isopropyl, isobuthyl, sec-butyl or terc-butyl; with the restriction that: X(n) cannot all be fluorine, and A be a single bond, and Y, as well as Z be O, and R′, as well as R″ be isopropyl, and R1 and R2 be hydrogen at the same time. The present invention further relates to pharmaceutical compositions comprising such compounds and to use of such compounds for treatment of disease states.
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Inventors:
Laszlo, Pouscus
Lihiana
Mornar, Esther
Lihiana
Mornar, Esther
Application Number:
JP2010512785A
Publication Date:
September 09, 2010
Filing Date:
June 20, 2008
Export Citation:
Assignee:
AVIDIN KFT
International Classes:
C07D209/48; A61K31/4035; A61K31/4439; A61K31/5377; A61P1/00; A61P9/10; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P43/00; C07D401/12
Attorney, Agent or Firm:
Patent Business Corporation Moegi Patent Office