Title:
N-(2-(ヘタリール)アリール)アリールスルホンアミドおよびN-(2-(ヘタリール)ヘタリール)アリールスルホンアミド
Document Type and Number:
Japanese Patent JP2010530875
Kind Code:
A
Abstract:
Compounds are provided that act as potent antagonists of the CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
Inventors:
Charvat, Trevor Tea
Hu, Chen
Merikian, Anita
Novak, Aaron
Andrew Pennell, Andrew M. Kay
Powers, jay
Panna, Three Nivas
Edward Sullivan
Thomas, William Dee
Angashe, Solomon
Chan, Pengly
Hu, Chen
Merikian, Anita
Novak, Aaron
Andrew Pennell, Andrew M. Kay
Powers, jay
Panna, Three Nivas
Edward Sullivan
Thomas, William Dee
Angashe, Solomon
Chan, Pengly
Application Number:
JP2010513380A
Publication Date:
September 16, 2010
Filing Date:
June 18, 2008
Export Citation:
Assignee:
Chemocentrix, Incorporated
International Classes:
C07D209/08; A61K31/404; A61K31/415; A61K31/416; A61K31/4164; A61K31/4192; A61K31/422; A61K31/427; A61K31/437; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/519; A61K31/5377; A61P1/04; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; C07D231/12; C07D231/14; C07D231/56; C07D233/61; C07D235/08; C07D249/06; C07D249/18; C07D401/04; C07D401/14; C07D403/06; C07D413/04; C07D413/14; C07D417/04; C07D471/04; C07D487/04
Domestic Patent References:
| JP2002511097A | 2002-04-09 | |||
| JP2005514413A | 2005-05-19 | |||
| JP2002510679A | 2002-04-09 |
Foreign References:
| US20050009871A1 | 2005-01-13 | |||
| WO2006076644A2 | 2006-07-20 | |||
| US20060183751A1 | 2006-08-17 | |||
| WO2003103647A1 | 2003-12-18 |
Other References:
JPN6013026242; Ｃｈｅｅｓｅｍａｎ，Ｇ．Ｗ．Ｈ．，ｅｔ ａｌ: Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ ２２（２）, 1985, ｐｐ４２３-４２７
JPN6013026243; Ｄｕｂｅｙ，Ｐ．Ｋ．，ｅｔ ａｌ: Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ， Ｓｅｃｔｉｏｎ Ｂ： Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｉｎｃｌｕｄｉｎｇ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４１Ｂ（６）, 2002, ｐｐ１３０５-１３０９
JPN6013026243; Ｄｕｂｅｙ，Ｐ．Ｋ．，ｅｔ ａｌ: Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ， Ｓｅｃｔｉｏｎ Ｂ： Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｉｎｃｌｕｄｉｎｇ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４１Ｂ（６）, 2002, ｐｐ１３０５-１３０９
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hirose Shinobu
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hirose Shinobu