Title:
脂肪酸アミドヒドロラーゼの三環系阻害剤
Document Type and Number:
Japanese Patent JP2010533645
Kind Code:
A
Abstract:
A series of substituted oxazole compounds having an alpha keto side chain at the 2 position and an aromatic, heteroaromatic or heterocycle substituent at the 5 position are disclosed. These compounds exhibit inhibition of fatty acid amid hydrolase and are useful for treatment of malconditions involving that enzyme.
Inventors:
Boger, Dale El.
Application Number:
JP2010510368A
Publication Date:
October 28, 2010
Filing Date:
May 30, 2008
Export Citation:
Assignee:
The Script Research Institute
International Classes:
C07D413/04; A61K31/135; A61K31/167; A61K31/195; A61K31/197; A61K31/4439; A61K31/616; A61K45/00; A61P43/00; C07D413/14; A61P1/04; A61P1/08; A61P1/12; A61P1/16; A61P3/04; A61P3/10; A61P9/10; A61P9/12; A61P11/00; A61P15/10; A61P15/18; A61P17/04; A61P19/02; A61P21/00; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/20; A61P25/22; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P37/06
Domestic Patent References:
| JP2006502229A | 2006-01-19 |
Foreign References:
| US20060167075A1 | 2006-07-27 | |||
| US20040127518A1 | 2004-07-01 | |||
| US6462054B1 | 2002-10-08 | |||
| WO2007098142A2 | 2007-08-30 | |||
| WO2008147553A1 | 2008-12-04 | |||
| US20060100212A1 | 2006-05-11 |
Other References:
JPN6013014662; Ｄａｌｅ Ｌ． Ｂｏｇｅｒ ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．４８, 2005, ｐ．１８４９-１８５６
JPN6013014663; Ｆ． Ａｎｔｈｏｎｙ Ｒｏｍｅｒｏ ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．５０, 200702, ｐ．１０５８-１０６８
JPN6013014664; Ｃｈｒｉｓｔｏｐｈｅ Ｈａｒｄｏｕｉｎ ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．５０, 2007, ｐ．３３５９-３３６８
JPN6013014663; Ｆ． Ａｎｔｈｏｎｙ Ｒｏｍｅｒｏ ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．５０, 200702, ｐ．１０５８-１０６８
JPN6013014664; Ｃｈｒｉｓｔｏｐｈｅ Ｈａｒｄｏｕｉｎ ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．５０, 2007, ｐ．３３５９-３３６８
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita