Title:
アンチセンス転写物を標的とするagRNAおよびギャップマーを用いた遺伝子発現の調節方法
Document Type and Number:
Japanese Patent JP2010539990
Kind Code:
A
Abstract:
Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.
More Like This:
| WO/2019/143829 | FASORACETAM CRYSTALLINE FORMS |
| JP2022532597 | How to treat cancer with CHK1 inhibitors |
| JP2010035501 | METHOD FOR POLYMORPHIC EVALUATION OF NUCLEIC ACID |
Inventors:
Schwartz Jacob See.
Younger Scott Tea.
Janowski Bethany A.
Korey David Earl.
Younger Scott Tea.
Janowski Bethany A.
Korey David Earl.
Application Number:
JP2010528200A
Publication Date:
December 24, 2010
Filing Date:
October 04, 2008
Export Citation:
Assignee:
Board of Regents The University of Texas System
International Classes:
C12Q1/68; C12N15/09
Foreign References:
| WO2007086990A2 | 2007-08-02 | |||
| WO2006130201A1 | 2006-12-07 | |||
| WO2007087113A2 | 2007-08-02 |
Other References:
JPN6013040766; Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｓｙｍｐｏｓｉｕｍ Ｓｅｒｉｅｓ Ｎｏ．４９, 2005, ｐ．３６７-３６８
JPN6013040770; Ｎａｔｕｒｅ Ｃｈｅｍｉｃａｌ Ｂｉｏｌｏｇｙ Ｖｏｌ．１， Ｎｏ．４, 2005, ｐ．２１６-２２２
JPN6013040770; Ｎａｔｕｒｅ Ｃｈｅｍｉｃａｌ Ｂｉｏｌｏｇｙ Ｖｏｌ．１， Ｎｏ．４, 2005, ｐ．２１６-２２２
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto