Title:
特定のヒドロキサム酸化合物の合成方法
Document Type and Number:
Japanese Patent JP2010540426
Kind Code:
A
Abstract:
The present invention pertains to the general field of chemical synthesis, and more particularly to methods for the synthesis of certain hydroxamic acid compounds, and in particular, (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide, also known as PXD101 and Belinostat®, comprising, for example, the steps of: (SAF) sulfonamide formation; (PURC) optional purification; (AAA) alkenyl-acid addition, comprising: either (i): the steps of, in order: (ACAEA) alkenyl-carboxylic acid ester addition; (PURE) optional purification; and (CAD) carboxylic acid deprotection; or (ii): the step of: (ACAA) alkenyl-carboxylic acid addition; (PURF) optional purification; (HAF) hydroxamic acid formation; and (PURG) optional purification.
Inventors:
Reish, Helga A.
Reaming, Peter
Rage, Prasard S.
Reaming, Peter
Rage, Prasard S.
Application Number:
JP2010525442A
Publication Date:
December 24, 2010
Filing Date:
September 23, 2008
Export Citation:
Assignee:
Topo Target UK Limited
International Classes:
C07C303/40; A61K31/18; A61P17/06; A61P35/00; A61P43/00; C07C303/38; C07C311/21
Domestic Patent References:
| JP2004511462A | 2004-04-15 | |||
| JP2003514904A | 2003-04-22 |
Other References:
JPN6013032501; Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ ８８（７）, 2005, ｐｐ． １６３０-１６５７
JPN7013002456; Ｊ． Ｍｅｄ． Ｃｈｅｍ． ４６（５）, 2003, ｐｐ． ８２０-８３０
JPN7013002456; Ｊ． Ｍｅｄ． Ｃｈｅｍ． ４６（５）, 2003, ｐｐ． ８２０-８３０
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Ishii Teiji
Satoshi Fujita
Eiichi Arai