Title:
鼻腔内組成物
Document Type and Number:
Japanese Patent JP2011503044
Kind Code:
A
Abstract:
The present invention provides a liquid aqueous formulation for the intranasal administration of apomorphine, which comprises:
(a) at least about 15 mg/ml of apomorphine; and
(b) a solubilising agent selected from
(i) at least one polyoxyethylene-polyoxypropylene copolymer (poloxamer);
(ii) at least one cyclodextrin; and
(iii)
at least one cyclodextrin together with chitosan. The formulations of the invention can be used in the treatment/management of Parkinson's disease.
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Inventors:
Peter Watts
Yui-Hoi Chen
Yui-Hoi Chen
Application Number:
JP2010532658A
Publication Date:
January 27, 2011
Filing Date:
November 10, 2008
Export Citation:
Assignee:
Archimedes Development Limited
International Classes:
A61K31/473; A61K9/08; A61K9/12; A61K47/34; A61K47/36; A61K47/40; A61P15/10; A61P25/16; C07D221/18
Domestic Patent References:
| JP2001524509A | 2001-12-04 | |||
| JP2006516272A | 2006-06-29 | |||
| JP2005526094A | 2005-09-02 | |||
| JP2005527535A | 2005-09-15 |
Foreign References:
| WO1992014473A1 | 1992-09-03 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro