Title:
高純度を有する2-[4-(3-または2-フルオロベンジルオキシ)ベンジルアミノ]プロパンアミドの製造方法
Document Type and Number:
Japanese Patent JP2011506375
Kind Code:
A
Abstract:
A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides, and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2-[4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to a reduction reaction with a reducing agent selected from sodium borohydride and potassium borohydride in an appropriate amount of an organic solvent selected from C 1 -C 5 lower alkanols, allowing the formation and presence during a substantial position of the reduction reaction course of a suspension of the Schiff base into the saturated solution of the Schiff base into the same organic solvent.
Inventors:
Barbantay, Elena
Hualabeturi, Laura
Salvati, Patricia
Kanebotsutei, Renato
Pontuzzini, Francisco
Hualabeturi, Laura
Salvati, Patricia
Kanebotsutei, Renato
Pontuzzini, Francisco
Application Number:
JP2010537377A
Publication Date:
March 03, 2011
Filing Date:
December 01, 2008
Export Citation:
Assignee:
Nyurong Fuma Mathematics Etspie Pear
International Classes:
C07C231/12; A61K31/165; A61P1/04; A61P3/00; A61P9/00; A61P13/00; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/16; A61P25/24; A61P25/28; A61P29/00; C07C237/04; C07C251/24
Domestic Patent References:
| JP2003529589A | 2003-10-07 |
Foreign References:
| WO2006027052A2 | 2006-03-16 |
Other References:
JPN6013035545; Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ． ４１, 1998, ５７９-５９０
Attorney, Agent or Firm:
Kawaguchi International Patent Office