Title:
2-アミノピリジン系キナーゼ阻害薬
Document Type and Number:
Japanese Patent JP2011511005
Kind Code:
A
Abstract:
2-Aminopyridine compounds having the structure of Formula I, and pharmaceutically acceptable salts of these compounds. Compounds of Formula I inhibit the activity of tyrosine kinase enzymes in animals, including humans, and are useful in the treatment and/or prevention of various diseases and conditions. In particular, compounds disclosed herein are inhibitors of kinases, in particular, but not limited to, KDR, Tie-2, Flt3, FGFR3, Ab1, Aurora A, c-Src, IGF-1R, ALK, c-MET, RON, PAK1, PAK2, and TAK1, and can be used in the treatment of proliferative diseases, such as, but not limited to, cancer. The present invention is also directed to a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The present invention is further directed to a method of treating a patient having a condition which is mediated by protein kinase activity by administering to the patient a therapeutically effective amount of the above-mentioned pharmaceutical composition.
Inventors:
Arjun Geh, Schutsteinig
Marvi Hill, Mark Theei
One, Chin
Warner, Douglas S
Won, Chinghua
Kang, Julie
Coat, heather
Chiang, Shin
Marvi Hill, Mark Theei
One, Chin
Warner, Douglas S
Won, Chinghua
Kang, Julie
Coat, heather
Chiang, Shin
Application Number:
JP2010545241A
Publication Date:
April 07, 2011
Filing Date:
February 02, 2009
Export Citation:
Assignee:
OSI Farma Sutraicals Incorporated
International Classes:
C07D401/04; A61K31/4439; A61K31/4725; A61K31/496; A61K31/5377; A61P35/00; A61P43/00; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D417/04; C07D417/14; C07D451/04
Domestic Patent References:
| JP2005516927A | 2005-06-09 | |||
| JP2011500778A | 2011-01-06 | |||
| JP2010513433A | 2010-04-30 |
Foreign References:
| WO2007147874A1 | 2007-12-27 | |||
| WO2006124874A2 | 2006-11-23 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office