Title:
5-リポキシゲナーゼ活性化タンパク質阻害剤
Document Type and Number:
Japanese Patent JP2011520982
Kind Code:
A
Abstract:
Described herein is the FLAP inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, or a pharmaceutically acceptable salt thereof. Also described are methods of preparing the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, including solvates, and polymorphs thereof. Also described herein are pharmaceutical compositions suitable for administration to a mammal that include the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, and methods of using such pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.
Inventors:
Kerb Murray
King, christopher david
Stock Nicholas Simon
King, christopher david
Stock Nicholas Simon
Application Number:
JP2011510719A
Publication Date:
July 21, 2011
Filing Date:
May 22, 2009
Export Citation:
Assignee:
Amira Pharmaceuticals, Inc.
International Classes:
C07D401/14; A61K9/08; A61K9/10; A61K9/20; A61K9/48; A61K31/444; A61K31/573; A61K45/00; A61K47/02; A61K47/10; A61K47/26; A61K47/34; A61K47/42; A61P1/04; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P25/04; A61P27/02; A61P29/02; A61P37/08; A61P43/00
Domestic Patent References:
| JP4705986B2 | 2011-06-22 |
Foreign References:
| WO2007056021A2 | 2007-05-18 |
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka