毒性を低減するためのドキソルビシンアジュバントおよびその使用法

Title:

毒性を低減するためのドキソルビシンアジュバントおよびその使用法

Document Type and Number:

Japanese Patent JP2011524851

Kind Code:

A

Abstract:

Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.

Inventors:

Garland William A.
Frenzel Bryan Dee.

Application Number:

JP2010546880A

Publication Date:

September 08, 2011

Filing Date:

February 11, 2009

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Tosk Incorporated

International Classes:

A61K31/704; A61K31/13; A61K31/192; A61P35/00; C07C323/32

Domestic Patent References:

JPH09507232A	1997-07-22
JP2007509840A	2007-04-19
JPH09507232A	1997-07-22
JP2007509840A	2007-04-19

Foreign References:

US20050192281A1	2005-09-01
WO2007118947A1	2007-10-25
US20030108484A1	2003-06-12
WO2007118947A1	2007-10-25
US20030108484A1	2003-06-12
US20050192281A1	2005-09-01

Other References:

JPN6013042732; Ｊ．　Ｍｅｄ．　Ｃｈｅｍ．Ｖｏｌ．４９, 2006, ｐ．２８１２-２８２０
JPN6013042730; Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ．Ｖｏｌ．２７５，　Ｎｏ．４３, 2000, ｐ．３３５８５-３３５９２
JPN6013042730; Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ．Ｖｏｌ．２７５，　Ｎｏ．４３, 2000, ｐ．３３５８５-３３５９２
JPN6013042732; Ｊ．　Ｍｅｄ．　Ｃｈｅｍ．Ｖｏｌ．４９, 2006, ｐ．２８１２-２８２０

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

Previous Patent: κ選択的オピオイド受容体アンタゴニスト

Next Patent: 新規なヒドラジド含有タキサン共役体