Title:
複素環γ-セクレターゼモジュレーター
Document Type and Number:
Japanese Patent JP2012508211
Kind Code:
A
Abstract:
The invention relates to methods for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome which comprise administering a therapeutically effective amount of a compound of formula I wherein R1, R2, R3, V, W, Y, and Z are as defined herein or a pharmaceutically active acid addition salt of such compounds. The invention also relates to a subgenus of such compounds and pharmaceutical compositions containing them, as well as methods for their manufacture.
Inventors:
Baumann, Karl Heinz
Getch, Erwin
Yoridon, Genese
Limberg, Anya
Lubbels, Thomas
Getch, Erwin
Yoridon, Genese
Limberg, Anya
Lubbels, Thomas
Application Number:
JP2011535094A
Publication Date:
April 05, 2012
Filing Date:
November 03, 2009
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D401/12; A61K31/4178; A61K31/4196; A61K31/4245; A61K31/427; A61K31/433; A61K31/4439; A61P25/00; A61P25/28; C07D403/12; C07D413/12; C07D417/12
Domestic Patent References:
| JP2007504282A | 2007-03-01 | |||
| JP2002528499A | 2002-09-03 | |||
| JP2010526847A | 2010-08-05 | |||
| JP2011512380A | 2011-04-21 | |||
| JP2007504282A | 2007-03-01 | |||
| JP2002528499A | 2002-09-03 |
Foreign References:
| WO2002057240A1 | 2002-07-25 | |||
| WO2002057240A1 | 2002-07-25 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito