Title:
C型肝炎ウイルス用の環状カルボキサミド化合物およびその類似体
Document Type and Number:
Japanese Patent JP2012509350
Kind Code:
A
Abstract:
The invention provides cyclic carboxamide compounds and analogues thereof of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R1, R6-R8, R16, R18, R19, M, n, T, Y, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. Certain cyclic carboxamide compounds and cyclic carboxamide analogues disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more cyclic carboxamide compounds or cyclic carboxamide analogues and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a cyclic carboxamide compound or cyclic carboxamide analogue as the only active agent or may contain a combination of a cyclic carboxamide compound or cyclic carboxamide analogue and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.
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Inventors:
Tsang Suming
Padke Avinash
Despandes Millindo
Gadachanda Venkato
Padke Avinash
Despandes Millindo
Gadachanda Venkato
Application Number:
JP2011537654A
Publication Date:
April 19, 2012
Filing Date:
November 20, 2009
Export Citation:
Assignee:
Achillion Pharmaceuticals, Incorporated
International Classes:
C07K5/083; A61K31/7056; A61K38/00; A61K38/21; A61P1/16; A61P31/14
Domestic Patent References:
| JP2002542160A | 2002-12-10 | |||
| JP2005524632A | 2005-08-18 |
Foreign References:
| WO2008106130A2 | 2008-09-04 | |||
| WO2008008502A1 | 2008-01-17 |
Attorney, Agent or Firm:
Patent Corporation yki International Patent Office