荷電4級アミノ基を含むポリマーによる核酸ベクターの改変

Japanese Patent JP2012511319

A

The present invention provides a polymer modified nucleic acid vector in which the nucleic acid vector is covalently linked to a polymer, which polymer comprises one or more positively charged quaternary amino groups, wherein the nucleic acid vector is a micro-organism selected from the group consisting of a virus, a bacteria or a bacteriophage, a fungus, a spore, a eukaryotic cell nucleus or other micro-organism fragment or a component containing genetic information, and wherein (a) the polymer and/or the linkages between it and the nucleic acid vector are hydrolytically, reducibly or enzymatically degradable; and/or (b) wherein each of the positively charged quaternary amino groups is linked to the polymer backbone via one or more degradable or biodegradable linkages.

JP2003500018	[Title of Invention] 48 human secretory proteins
JP2003199578	IDENTIFICATION OF DISEASE-SENSITIVE GENE LOCUS AND GLUTAMIC ACID RECEPTOR GENE AS A SCHIZOPHRENIC DISEASE SENSITIVE GENE
JPH08506734	INDUSTRIAL APPLICABILITY Antisense oligos that interfere with mRNA cap activity and inhibit translation.

Leonard William Sameur
Karel Urbrich

JP2011540186A

May 24, 2012

December 11, 2008

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Cyoxus Therapeutics Limited

C12N15/09; A61K31/7088; C12N15/63; A61K35/74; A61K35/76; A61K38/22; A61K39/395; A61K45/00; A61K47/48; A61K48/00; A61P43/00; C12N15/11; C12N15/113; C12N15/86

WO1995006056A1	1995-03-02
WO2006085664A1	2006-08-17

JPN6013045717; Ｇｅｎｅ　Ｔｈｅｒａｐｙ Ｖｏｌ．１１, 2004, ｐ．１２５６-１２６３
JPN6013045719; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｇｅｎｅ　Ｍｅｄｉｃｉｎｅ Ｖｏｌ．１０, 200801, ｐ．４００-４１１
JPN6013045721; Ｇｅｎｅ　Ｔｈｅｒａｐｙ Ｖｏｌ．８, 2001, ｐ．３４１-３４８
JPN6013045723; Ｊｏｕｒｎａｌ　ｏｆ　Ｃｏｎｔｒｏｌｌｅｄ　Ｒｅｌｅａｓｅ Ｖｏｌ．８１, 2002, ｐ．２０１-２１７

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Kenji Chatan

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